ArticlePloS one2012
Quantitative analysis of monocyte subpopulations in murine atherosclerotic plaques by multiphoton microscopy.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Signaling pathways regulating the extracellular digestion of lipoprotein aggregates by macrophages.Molecular biology of the cell · 2024Article
- Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- Intravital Microscopy in Atherosclerosis Research.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering.Basic research in cardiology · 2020Article
- Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice.Nature medicine · 2018Article
- Limited Macrophage Positional Dynamics in Progressing or Regressing Murine Atherosclerotic Plaques-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- 13-Series resolvins mediate the leukocyte-platelet actions of atorvastatin and pravastatin in inflammatory arthritis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- En Face Preparation of Mouse Blood Vessels.Journal of visualized experiments : JoVE · 2017Article
- Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- Live cell imaging to understand monocyte, macrophage, and dendritic cell function in atherosclerosis.The Journal of experimental medicine · 2016Review
- Nonclassical patrolling monocyte function in the vasculature.Arteriosclerosis, thrombosis, and vascular biology · 2015Review
- Imaging of small animal peripheral artery disease models: recent advancements and translational potential.International journal of molecular sciences · 2015Review
- Mechanisms that regulate macrophage burden in atherosclerosis.Circulation research · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The progressive accumulation of monocyte-derived cells in the atherosclerotic plaque is a hallmark of atherosclerosis. However, it is now appreciated that monocytes represent a heterogeneous circulating population of cells that differ in functionality. New approaches are needed to investigate the role of monocyte subpopulations in atherosclerosis since a detailed understanding of their differential mobilization, recruitment, survival and emigration during atherogenesis is of particular importance for development of successful therapeutic strategies. We present a novel methodology for the in vivo examination of monocyte subpopulations in mouse models of atherosclerosis. This approach combines cellular labeling by fluorescent beads with multiphoton microscopy to visualize and monitor monocyte subpopulations in living animals. First, we show that multiphoton microscopy is an accurate and timesaving technique to analyze monocyte subpopulation trafficking and localization in plaques in excised tissues. Next, we demonstrate that multiphoton microscopy can be used to monitor monocyte subpopulation trafficking in atherosclerotic plaques in living animals. This novel methodology should have broad applications and facilitate new insights into the pathogenesis of atherosclerosis and other inflammatory diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.