ArticlePloS one2012
The dose-response decrease in heart rate variability: any association with the metabolites of polycyclic aromatic hydrocarbons in coke oven workers?
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Age-related DNA methylation on Y chromosome and their associations with total mortality among Chinese males.Aging cell · 2022Pooled it
- Human Biomonitoring of Environmental and Occupational Exposures by GC-MS and Gas Sensor Systems: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Persistent Organic Pollutants and Heart Rate Variability: A Population-Based Cross-Sectional Study in China.Journal of the American Heart Association · 2025Article
- Article
- Circulating microRNAs as biomarkers of environmental exposure to polycyclic aromatic hydrocarbons: potential and prospects.Environmental science and pollution research international · 2021Review
- Polycyclic aromatic hydrocarbons associated long non-coding RNAs and heart rate variability in coke oven workers.Environmental science and pollution research international · 2021Article
- Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function.Environmental health : a global access science source · 2020Article
- Cardiovascular Disease-Related Serum Proteins in Workers Occupationally Exposed to Polycyclic Aromatic Hydrocarbons.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Potential role of polycyclic aromatic hydrocarbons as mediators of cardiovascular effects from combustion particles.Environmental health : a global access science source · 2019Review
- Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging.Environmental health perspectives · 2018Article
- Urinary polycyclic aromatic hydrocarbon metabolites and adult asthma: a case-control study.Scientific reports · 2018Article
- Effects of coke oven emissions and benzo[a]pyrene on blood pressure and electrocardiogram in coke oven workers.Journal of occupational health · 2017Article
- The relationship between ambient carbon monoxide and heart rate variability-a systematic world review-2015.Environmental science and pollution research international · 2016Review
- Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population.Environmental health perspectives · 2016Article
- Urinary Metabolites of Polycyclic Aromatic Hydrocarbons and the Association with Lipid Peroxidation: A Biomarker-Based Study between Los Angeles and Beijing.Environmental science & technology · 2016Article
- Exposure to Polycyclic Aromatic Hydrocarbons, Plasma Cytokines, and Heart Rate Variability.Scientific reports · 2016Article
- Metabolism of benzo(a)pyrene by aortic subcellular fractions in the setting of abdominal aortic aneurysms.Molecular and cellular biochemistry · 2016Article
- Chemical composition modulates the adverse effects of particles on the mucociliary epithelium.Clinics (Sao Paulo, Brazil) · 2015Article
- Urinary metals and heart rate variability: a cross-sectional study of urban adults in Wuhan, China.Environmental health perspectives · 2015Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAir pollution has been associated with an increased risk of cardiopulmonary mortality and decreased heart rate variability (HRV). However, it is unclear whether coke oven emissions (COEs) and polycyclic aromatic hydrocarbons (PAHs) are associated with HRV.
objectivesOur goal in the present study was to investigate the association of exposure to COEs and the urinary metabolite profiles of PAHs with HRV of coke oven workers.
methodsWe measured benzene soluble matter, carbon monoxide, sulfur dioxide, particulate matters, and PAHs at different workplaces of a coke oven plant. We determined 10 urinary PAH metabolites and HRV indices of 1333 workers using gas chromatography-mass spectrometry and a 3-channel digital Holter monitor, respectively.
resultsOur results showed that there was a significant COEs-related dose-dependent decrease in HRV, and an inverse relationship between the quartiles of urinary 2-hydroxynaphthalene and five HRV indices (p(trend)<0.01 for all). After adjustment for potential confounders, elevation per interquartile range (IQR) (1.81 µg/mmol creatinine) of urinary 2-hydroxynaphthalene was associated with a 5.46% (95% CI, 2.50-8.32) decrease in standard deviation of NN intervals (SDNN). As workers worked more years, SDNN gradually declined in the same quartiles of 2-hydroxynaphthalene levels (p(trend) = 1.40×10(-4)), especially in workers with the highest levels of 2-hydroxynaphthalene.
conclusionsOccupational exposure to COEs is associated with a dose-response decrease in HRV. In particular, increased exposure to 2-hydroxynaphthalene is associated with significantly decreased HRV. Increase of working years and exposure levels has resulted in a gradual decline of HRV.
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