ArticleIndian journal of clinical biochemistry : IJCB2011
A review on salivary genomics and proteomics biomarkers in oral cancer.
Article in Indian journal of clinical biochemistry : IJCB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 154 citations in OpenAlex.
- Yogic breathing when compared to attention control reduces the levels of pro-inflammatory biomarkers in saliva: a pilot randomized controlled trial.BMC complementary and alternative medicine · 2016Trial
- Spatial transcriptomics reveals molecular differences associated with malignant transformation in oral epithelial dysplasia.Frontiers in immunology · 2026Article
- Proteomic identification and histopathological validation of candidate biomarkers CA1, HBB, Torsin A, andFrontiers in medicine · 2026Article
- FTIR-based machine learning for prediction of malignant transformation in oral epithelial dysplasia.The Analyst · 2025Article
- Salivary biomarkers: a promising approach for predicting immunotherapy response in head and neck cancers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Review
- Decoding Salivary ncRNAomes as Novel Biomarkers for Oral Cancer Detection and Prognosis.Non-coding RNA · 2025Review
- Evaluation of salivary lactate dehydrogenase level among tobacco users - A hospital based study.Bioinformation · 2025Article
- The expression of salivary EGF, VEGF, endothelin, and transferrin in waterpipe and cigarette smokers.Odontology · 2025Observational
- The Role of Oral Biomarkers in the Assessment of Noncommunicable Diseases.Diagnostics (Basel, Switzerland) · 2024Review
- Evaluation of salivary transferrin in patients with oral squamous cell carcinoma.Clinical and experimental dental research · 2024Article
- Advances and Challenges in Nanomaterial-Based Electrochemical Immunosensors for Small Cell Lung Cancer Biomarker Neuron-Specific Enolase.ACS omega · 2024Review
- Salivary biomarkers in non-invasive oral cancer diagnostics: a comprehensive review.Journal of applied oral science : revista FOB · 2024Review
- Analysis of salivary alpha-L-fucosidase and salic acid among oral sub-mucous fibrosis patients.Bioinformation · 2024Article
- Review Insights on Salivary Proteomics Biomarkers in Oral Cancer Detection and Diagnosis.Molecules (Basel, Switzerland) · 2023Review
- Serum and Saliva LDH Levels in Patients with Habit, Oral Potentially Malignant Disorders (OPMDs), and Oral Squamous Cell Carcinoma (OSCC): A Spectrophotometry Study.Journal of pharmacy & bioallied sciences · 2023Article
- Review
- Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2022Review
- Microbiota in Periodontitis: Advances in the Omic Era.Advances in experimental medicine and biology · 2022Review
- Oral Cancer Discrimination and Novel Oral Epithelial Dysplasia Stratification Using FTIR Imaging and Machine Learning.Diagnostics (Basel, Switzerland) · 2021Article
- Salivaomics for Oral Cancer Detection: An Insight.Journal of pharmacy & bioallied sciences · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral cancer has emerged as an alarming public health problem with increasing incidence and mortality rates all over the world. Therefore, the implementation of newer screening and early detection approaches are of utmost importance which could reduce the morbidity and mortality associated with this disease. Sensitive and specific biomarkers for oral cancer are likely to be most effective for screening, diagnosis, staging and follow-up for this dreaded malignancy. Unlike other deep cancers, oral cancer is located in oral cavity. Hence, the direct contact between saliva and oral cancer lesion makes the measurement of tumor markers in saliva an attractive alternative to serum and tissue testing. The DNA, RNA and protein molecules derived from the living cancer cells can be conveniently obtained from saliva. Thus, salivary biomarkers, a non-invasive alternative to serum and tissue-based biomarkers may be an effective modality for early diagnosis, prognostication and monitoring post therapy status. In the current post-genomic era, various technologies provide opportunities for high-throughput approaches to genomics and proteomics; which have been used to evaluate altered expressions of gene and protein targets in saliva of oral cancer patients. The emerging field of salivary biomarkers has great potentials to prove its clinical significance to combat oral cancer. Hence, we have reviewed importance of several salivary genomics and proteomics biomarkers for oral cancer.
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Registered trials
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