ArticleSleep2012
Circadian modulation of consolidated memory retrieval following sleep deprivation in Drosophila.
Article in Sleep, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Peroxisomal import is circadian in glia and regulates sleep and lipid metabolism.PLoS biology · 2026Article
- Article
- The Interactive Role of Sleep and Circadian Rhythms in Episodic Memory in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Review
- The Devastating Effects of Sleep Deprivation on Memory: Lessons from Rodent Models.Clocks & sleep · 2023Review
- Sleep contributes to preference for novel food odours in Drosophila melanogaster.Scientific reports · 2021Article
- Neural Circuits Underlying Behavioral Flexibility: Insights FromFrontiers in behavioral neuroscience · 2021Review
- Regulation of Olfactory Associative Memory by the Circadian Clock Output Signal Pigment-Dispersing Factor (PDF).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Sleep restores place learning to the adenylyl cyclase mutantJournal of neurogenetics · 2020Article
- Sleep regulates visual selective attention inThe Journal of experimental biology · 2018Article
- The clock gene period differentially regulates sleep and memory in Drosophila.Neurobiology of learning and memory · 2018Article
- Sleep supports inhibitory operant conditioning memory inLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Article
- Recurrent Sleep Fragmentation Induces Insulin and Neuroprotective Mechanisms in Middle-Aged Flies.Frontiers in aging neuroscience · 2016Article
- The Yin and Yang of Sleep and Attention.Trends in neurosciences · 2015Review
- Circadian pacemaker neurons change synaptic contacts across the day.Current biology : CB · 2014Article
- Drosophila adult olfactory shock learning.Journal of visualized experiments : JoVE · 2014Article
- Unraveling the complexities of circadian and sleep interactions with memory formation through invertebrate research.Frontiers in systems neuroscience · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectivesSeveral lines of evidence indicate that sleep plays a critical role in learning and memory. The aim of this study was to evaluate anesthesia resistant memory following sleep deprivation in Drosophila.
designFour to 16 h after aversive olfactory training, flies were sleep deprived for 4 h. Memory was assessed 24 h after training. Training, sleep deprivation, and memory tests were performed at different times during the day to evaluate the importance of the time of day for memory formation. The role of circadian rhythms was further evaluated using circadian clock mutants.
resultsMemory was disrupted when flies were exposed to 4 h of sleep deprivation during the consolidation phase. Interestingly, normal memory was observed following sleep deprivation when the memory test was performed during the 2 h preceding lights-off, a period characterized by maximum wake in flies. We also show that anesthesia resistant memory was less sensitive to sleep deprivation in flies with disrupted circadian rhythms.
conclusionsOur results indicate that anesthesia resistant memory, a consolidated memory less costly than long-term memory, is sensitive to sleep deprivation. In addition, we provide evidence that circadian factors influence memory vulnerability to sleep deprivation and memory retrieval. Taken together, the data show that memories weakened by sleep deprivation can be retrieved if the animals are tested at the optimal circadian time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.