ArticleJournal of immunology (Baltimore, Md. : 1950)2012
The Yaa locus and IFN-α fine-tune germinal center B cell selection in murine systemic lupus erythematosus.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 28 citations in OpenAlex.
- The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus.Nature reviews. Rheumatology · 2024Review
- Emerging concepts of type I interferons in SLE pathogenesis and therapy.Nature reviews. Rheumatology · 2022Review
- Rubicon promotes rather than restricts murine lupus and is not required for LC3-associated phagocytosis.JCI insight · 2022Article
- Context-dependent induction of autoimmunity by TNF signaling deficiency.JCI insight · 2022Article
- Type II but Not Type I IFN Signaling Is Indispensable for TLR7-Promoted Development of Autoreactive B Cells and Systemic Autoimmunity.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- BAFF inhibition in SLE-Is tolerance restored?Immunological reviews · 2019Review
- B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for Loss of Tolerance and the Development of Autoreactive B Cells.Cell reports · 2018Article
- Spontaneous germinal centers and autoimmunity.Autoimmunity · 2017Review
- Use of Toll-Like Receptor Agonists to Induce Ectopic Lymphoid Structures in Myasthenia Gravis Mouse Models.Frontiers in immunology · 2017Article
- DNA-reactive B cells in lupus.Current opinion in immunology · 2016Review
- Germinal centers and autoimmune disease in humans and mice.Immunology and cell biology · 2016Review
- Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance.Cell reports · 2016Article
- The Effect of BAFF Inhibition on Autoreactive B-Cell Selection in Murine Systemic Lupus Erythematosus.Molecular medicine (Cambridge, Mass.) · 2016Article
- Phenotypic and functional alterations of pDCs in lupus-prone mice.Scientific reports · 2016Article
- Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Maintenance of autoantibody production in pristane-induced murine lupus.Arthritis research & therapy · 2015Article
- Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus.Clinical and experimental immunology · 2015Article
- Modulation of Igβ is essential for the B cell selection in germinal center.Scientific reports · 2015Article
- Deficiency of fibroblast growth factor-inducible 14 (Fn14) preserves the filtration barrier and ameliorates lupus nephritis.Journal of the American Society of Nephrology : JASN · 2015Article
- Defects in Germinal Center Selection in SLE.Frontiers in immunology · 2015Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Male NZW/BXSB.Yaa (W/B) mice express two copies of TLR7 and develop pathogenic autoantibodies, whereas females with only one copy of TLR7 have attenuated disease. Our goal was to analyze the regulation of the autoantibody response in male and female W/B mice bearing the autoreactive site-directed H chain transgene 3H9. Serum anti-dsDNA Abs appeared in males at 12 wk, and most had high-titer IgG anti-dsDNA and anti-cardiolipin Abs and developed >300 mg/dl proteinuria by 8 mo. Females had only low-titer IgG anti-cardiolipin Abs, and none developed proteinuria by 1 y. Males had a smaller marginal zone than females with a repertoire that was distinct from the follicular repertoire, indicating that the loss of marginal zone B cells was not due to diversion to the follicular compartment. Vk5-43 and Vk5-48, which were rare in the naive repertoire, were markedly overrepresented in the germinal center repertoire of both males and females, but the VJ junctions differed between males and females with higher-affinity autoreactive B cells being selected into the germinal centers of males. Administration of IFN-α to females induced anti-cardiolipin and anti-DNA autoantibodies and proteinuria and was associated with a male pattern of junctional diversity in Vk5-43 and Vk5-48. Our studies are consistent with the hypothesis that presence of the Yaa locus, which includes an extra copy of Tlr7, or administration of exogenous IFN-α relaxes the stringency for selection in the germinal centers resulting in increased autoreactivity of the Ag-driven B cell repertoire.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.