ArticleAngewandte Chemie (International ed. in English)2012
Heterologous expression and manipulation of three tetracycline biosynthetic pathways.
Article in Angewandte Chemie (International ed. in English), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- AI-Assisted Isolation of Bioactive Dipyrimicins fromJournal of natural products · 2026Article
- Development of a versatile chassis for the efficient production of diverse type II polyketides.Nature communications · 2025Article
- AI-assisted isolation of bioactive Dipyrimicins frombioRxiv : the preprint server for biology · 2025Article
- ActVI-ORFA directs metabolic flux towards actinorhodin by preventing intermediate degradation.PloS one · 2024Article
- Resistance and phylogeny guided discovery reveals structural novelty of tetracycline antibiotics.Chemical science · 2022Article
- High-Titer Production of the Fungal Anhydrotetracycline, TAN-1612, in Engineered Yeasts.ACS synthetic biology · 2022Article
- Crystal structure determination of the halogenase CtcP from Streptomyces aureofaciens.Acta crystallographica. Section F, Structural biology communications · 2022Article
- Cofactor F420: an expanded view of its distribution, biosynthesis and roles in bacteria and archaea.FEMS microbiology reviews · 2021Article
- Heterologous Catalysis of the Final Steps of Tetracycline Biosynthesis byACS chemical biology · 2021Article
- Synthetic biology approaches to actinomycete strain improvement.FEMS microbiology letters · 2021Review
- Photocatalytic Reductive Radical-Polar Crossover for a Base-Free Corey-Seebach Reaction.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Metabolic engineering of a methyltransferase for production of drug precursors demecycline and demeclocycline inSynthetic and systems biotechnology · 2020Article
- CtcS, a MarR family regulator, regulates chlortetracycline biosynthesis.BMC microbiology · 2019Article
- Rewriting the Metabolic Blueprint: Advances in Pathway Diversification in Microorganisms.Frontiers in microbiology · 2018Review
- Biosynthesis of Oxytetracycline byFood technology and biotechnology · 2017Review
- Physiology, Biochemistry, and Applications of F420- and Fo-Dependent Redox Reactions.Microbiology and molecular biology reviews : MMBR · 2016Review
- A comprehensive review of glycosylated bacterial natural products.Chemical Society reviews · 2015Review
- Reinvigorating natural product combinatorial biosynthesis with synthetic biology.Nature chemical biology · 2015Article
- Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus.Microbial cell factories · 2015Article
- Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides.Journal of industrial microbiology & biotechnology · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A very accommodating host: Three tetracycline biosynthetic pathways were overexpressed and manipulated in the heterologous host Streptomyces lividans K4-114. Through the inactivation of various genes and characterization of the resulting biosynthetic intermediates, new tetracycline-modifying enzymes were identified (see scheme).
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Registered trials
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