SynthesisReviews on environmental health2012
Effect of particulate matter air pollution on C-reactive protein: a review of epidemiologic studies.
Synthesis in Reviews on environmental health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Modeling vascular inflammation and atherogenicity after inhalation of ambient levels of ozone: exploratory lessons from transcriptomics.Inhalation toxicology · 2017Pooled it
- Airway and systemic biomarkers of health effects after short-term exposure to indoor ultrafine particles from cooking and candles - A randomized controlled double-blind crossover study among mild asthmatic subjects.Particle and fibre toxicology · 2023Trial
- Trial
- The impacts of traffic-related and woodsmoke particulate matter on measures of cardiovascular health: a HEPA filter intervention study.Occupational and environmental medicine · 2015Trial
- Controlled exposure to particulate matter from urban street air is associated with decreased vasodilation and heart rate variability in overweight and older adults.Particle and fibre toxicology · 2015Trial
- An indoor air filtration study in homes of elderly: cardiovascular and respiratory effects of exposure to particulate matter.Environmental health : a global access science source · 2013Trial
- Can Panax ginseng help protect the body from the harmful effects of airborne particulate matter?Journal of ginseng research · 2025Review
- Assessment of ventilatory functions and associated inflammatory markers among workers in slaughterhouses.International archives of occupational and environmental health · 2024Article
- Associations between short-term exposure to ambient air pollution and lung function in adults.Journal of exposure science & environmental epidemiology · 2024Article
- The Effects of Environmental Pollutants and Exposures on Hair Follicle Pathophysiology.Skin appendage disorders · 2024Review
- A cohort study of the multipollutant effects of PMEnvironmental epidemiology (Philadelphia, Pa.) · 2024Article
- Indoor and ambient black carbon and fine particulate matter associations with blood biomarkers in COPD patients.The Science of the total environment · 2024Article
- Article
- Particulate matter, traffic-related air pollutants, and circulating C-reactive protein levels: The Multiethnic Cohort Study.Environmental pollution (Barking, Essex : 1987) · 2023Article
- Relationship between urinary biomarkers of early kidney damage and exposure to inorganic toxins in a pediatric population of Apizaco, Tlaxcala, Mexico.Journal of nephrology · 2023Article
- Toxicological Effects of Fine Particulate Matter (PMWater, air, and soil pollution · 2023Review
- Short-term effect of ambient air pollution on outpatient visits for children in Guangzhou, China.Frontiers in public health · 2023Article
- Occupational exposure to particles and biomarkers of cardiovascular disease-during work and after vacation.International archives of occupational and environmental health · 2022Article
- Article
- Aneurysmal Subarachnoid Hemorrhage during the Shutdown for COVID-19.Journal of clinical medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Inflammatory response is implicated as a biologic mechanism that links particulate matter (PM) air pollution with health effects. C-reactive protein (CRP), an important acutephase reactant with profound proinflammatory properties, is used clinically as an indicator of the presence and intensity of inflammation. In vitro and in vivo animal studies suggest that CRP levels increase in response to PM exposure, but there was no consistency in epidemiologic studies. Herein, a systematic review was conducted to examine the association between PM exposure and serum CRP levels in humans. Elevated CRP levels were consistently found among children, and CRP elevations were also observed among healthy adults, albeit requiring higher peak levels of PM exposure. PM-induced CRP responses were not consistently found in adults with chronic inflammatory conditions, perhaps because of the use of anti-inflammatory medications in this population. Of the eight examined randomized trials, only one trial with a longer intervention period supported the effect of PM exposure on CRP concentrations. To provide conclusive evidence, further epidemiologic studies are needed to better quantify the magnitude of CRP level changes in response to PM with well-defined study populations and better control of various confounding factors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.