ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Altered hemodynamics, endothelial function, and protein expression occur with aortic coarctation and persist after repair.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Severity and duration-dependent aortic stiffening in a rabbit coarctation model identifies constitutive material parameters as promising regional biomarkers for hypertension progression.Scientific reports · 2026Article
- Hemodynamic and developmental biomarkers enhance prenatal coarctation prediction: a validated multiparametric ultrasound model.Archives of gynecology and obstetrics · 2025Article
- A Novel Diastolic Doppler Index Less Affected by Aortic Arch Anomalies Co-existing with Coarctation.Pediatric cardiology · 2025Article
- Computational model of coarctation of the aorta in rabbits suggests persistent ascending aortic remodeling post-correction.Biomechanics and modeling in mechanobiology · 2025Article
- Surgically induced aortic coarctation in a neonatal porcine model allows for longitudinal assessment of cardiovascular changes.American journal of physiology. Heart and circulatory physiology · 2024Article
- Coarctation Duration and Severity Predict Risk of Hypertension Precursors in a Preclinical Model and Hypertensive Status Among Patients.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Coarctation duration and severity predict risk of hypertension precursors in a preclinical model and hypertensive status among patients.medRxiv : the preprint server for health sciences · 2024Article
- Consistency of the continuous flow pressure gradient despite aortic arch anomalies co-existing with coarctation.medRxiv : the preprint server for health sciences · 2023Article
- Aortic Remodeling Kinetics in Response to Coarctation-Induced Mechanical Perturbations.Biomedicines · 2023Article
- Temporal evolution of mechanical stimuli from vascular remodeling in response to the severity and duration of aortic coarctation in a preclinical model.Scientific reports · 2023Article
- A workflow for viewing biomedical computational fluid dynamics results and corresponding data within virtual and augmented reality environments.Frontiers in medical technology · 2023Article
- Clinical, Experimental, and Computational Validation of a New Doppler-Based Index for Coarctation Severity Assessment.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2022Article
- Follow-up of hypertension after aortic coarctation stent implantation based on safe and effective re-intervention: a retrospective cohort study.Journal of thoracic disease · 2022Article
- Impact of extra-anatomical bypass on coarctation fluid dynamics using patient-specific lumped parameter and Lattice Boltzmann modeling.Scientific reports · 2022Article
- Validation and Diagnostic Performance of a CFD-Based Non-invasive Method for the Diagnosis of Aortic Coarctation.Frontiers in neuroinformatics · 2020Article
- Human genotyping and an experimental model reveal NPR-C as a possible contributor to morbidity in coarctation of the aorta.Physiological genomics · 2019Article
- Predictive factors for residual hypertension following aortic coarctation stenting.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Computational Fluid Dynamics of Vascular Disease in Animal Models.Journal of biomechanical engineering · 2018Review
- Are aortic coarctation and rheumatoid arthritis different models of aortic stiffness? Data from an echocardiographic study.Cardiovascular ultrasound · 2018Article
- Treating a 20 mm Hg gradient alleviates myocardial hypertrophy in experimental aortic coarctation.The Journal of surgical research · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Coarctation of the aorta (CoA) is associated with substantial morbidity despite treatment. Mechanically induced structural and functional vascular changes are implicated; however, their relationship with smooth muscle (SM) phenotypic expression is not fully understood. Using a clinically representative rabbit model of CoA and correction, we quantified mechanical alterations from a 20-mmHg blood pressure (BP) gradient in the thoracic aorta and related the expression of key SM contractile and focal adhesion proteins with remodeling, relaxation, and stiffness. Systolic and mean BP were elevated for CoA rabbits compared with controls leading to remodeling, stiffening, an altered force response, and endothelial dysfunction both proximally and distally. The proximal changes persisted for corrected rabbits despite >12 wk of normal BP (~4 human years). Computational fluid dynamic simulations revealed reduced wall shear stress (WSS) proximally in CoA compared with control and corrected rabbits. Distally, WSS was markedly increased in CoA rabbits due to a stenotic velocity jet, which has persistent effects as WSS was significantly reduced in corrected rabbits. Immunohistochemistry revealed significantly increased nonmuscle myosin and reduced SM myosin heavy chain expression in the proximal arteries of CoA and corrected rabbits but no differences in SM α-actin, talin, or fibronectin. These findings indicate that CoA can cause alterations in the SM phenotype contributing to structural and functional changes in the proximal arteries that accompany the mechanical stimuli of elevated BP and altered WSS. Importantly, these changes are not reversed upon BP correction and may serve as markers of disease severity, which explains the persistent morbidity observed in CoA patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.