ArticleArthritis and rheumatism2012
European genetic ancestry is associated with a decreased risk of lupus nephritis.
Article in Arthritis and rheumatism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Polymorphisms of BLK are associated with renal disorder in patients with systemic lupus erythematosus.Journal of human genetics · 2020Pooled it
- Genetic contributions to lupus nephritis in a multi-ethnic cohort of systemic lupus erythematous patients.PloS one · 2018Trial
- Treatment of lupus nephritis with abatacept: the Abatacept and Cyclophosphamide Combination Efficacy and Safety Study.Arthritis & rheumatology (Hoboken, N.J.) · 2014Trial
- Genomic Landscape of Systemic Lupus Erythematosus and Lupus Nephritis Globally and the Gaps in Africa.International journal of molecular sciences · 2026Review
- Prediction model for renal outcomes in Latin American Mestizo patients with pure proliferative lupus nephritis.Lupus science & medicine · 2025Article
- Local Ancestry at the Major Histocompatibility Complex Region is Not a Major Contributor to Disease Heterogeneity in a Multiethnic Lupus Cohort.Arthritis & rheumatology (Hoboken, N.J.) · 2024Article
- Article
- Molecular pathways identified from single nucleotide polymorphisms demonstrate mechanistic differences in systemic lupus erythematosus patients of Asian and European ancestry.Scientific reports · 2023Article
- Transcriptome Studies in Lupus Nephritis.Archivum immunologiae et therapiae experimentalis · 2022Review
- Multi-ethnic Investigation of Risk and Immune Determinants of COVID-19 Outcomes.Research square · 2022Article
- Proteinuria and serum creatinine after 12 months of treatment for lupus nephritis as predictors of long-term renal outcome: a case-control study.Advances in rheumatology (London, England) · 2022Article
- Multiethnic Investigation of Risk and Immune Determinants of COVID-19 Outcomes.Frontiers in cellular and infection microbiology · 2022Article
- Evidence that geographic variation in genetic ancestry associates with uterine fibroids.Human genetics · 2021Article
- Predictors of the start of declining eGFR in patients with systemic lupus erythematosus.Lupus · 2021Article
- Effect of a Single Apolipoprotein L1 Gene Nephropathy Variant on the Risk of Advanced Lupus Nephritis in Brazilians.The Journal of rheumatology · 2020Article
- Lupus patient decisions about clinical trial participation: a qualitative evaluation of perceptions, facilitators and barriers.Lupus science & medicine · 2020Article
- A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus.Nature communications · 2019Article
- Unraveling Race, Socioeconomic Factors, and Geographical Context in the Heterogeneity of Lupus Mortality in the United States.ACR open rheumatology · 2019Article
- Engaging African ancestry participants in SLE clinical trials.Lupus science & medicine · 2018Article
- Prognostic significance of repeat biopsy in lupus nephritis: Histopathologic worsening and a short time between biopsies is associated with significantly increased risk for end stage renal disease and death.Clinical immunology (Orlando, Fla.) · 2017Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveAfrican Americans, East Asians, and Hispanics with systemic lupus erythematosus (SLE) are more likely to develop renal disease than are SLE patients of European descent. This study was undertaken to investigate whether European genetic ancestry protects against the development of lupus nephritis, with the aim of exploring the genetic and socioeconomic factors that might explain this effect.
methodsThis was a cross-sectional study of SLE patients from a multiethnic case collection. Participants were genotyped for 126 single-nucleotide polymorphisms (SNPs) informative for ancestry. A subset of participants was also genotyped for 80 SNPs in 14 candidate genes for renal disease in SLE. Logistic regression was used to test the association between European ancestry and renal disease. Analyses were adjusted for continental ancestries, socioeconomic status (SES), and candidate genes.
resultsParticipants (n = 1,906) had, on average, 62.4% European, 15.8% African, 11.5% East Asian, 6.5% Amerindian, and 3.8% South Asian ancestry. Among the participants, 656 (34%) had renal disease. A 10% increase in the proportion of European ancestry estimated in each participant was associated with a 15% reduction in the odds of having renal disease, after adjustment for disease duration and sex (odds ratio 0.85, 95% confidence interval 0.82-0.87; P = 1.9 × 10(-30) ). Adjustment for other genetic ancestries, measures of SES, or SNPs in the genes most associated with renal disease (IRF5 [rs4728142], BLK [rs2736340], STAT4 [rs3024912], and HLA-DRB1*0301 and DRB1*1501) did not substantively alter this relationship.
conclusionEuropean ancestry is protective against the development of renal disease in SLE, an effect that is independent of other genetic ancestries, candidate risk alleles, and socioeconomic factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.