ArticleCell cycle (Georgetown, Tex.)2012
Suppression of centrosome duplication and amplification by deacetylases.
Article in Cell cycle (Georgetown, Tex.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- A cell cycle-dependent transition of acetylation to phosphorylation regulates timely centrosome maturation.Nature communications · 2026Article
- GATAD2B regulates spindle assembly by affecting protein deacetylation during oocyte meiotic maturation.Animal bioscience · 2025Article
- Evidence that HDAC7 acts as an epigenetic "reader" of AR acetylation through NCoR-HDAC3 dissociation.Cell chemical biology · 2022Article
- Article
- Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential.BMC cancer · 2020Article
- HDAC3 and HDAC8 are required for cilia assembly and elongation.Biology open · 2019Article
- Overcome cancer drug resistance by targeting epigenetic modifications of centrosome.Cancer drug resistance (Alhambra, Calif.) · 2019Review
- Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication.Cell reports · 2018Article
- Functions and dysfunctions of the mammalian centrosome in health, disorders, disease, and aging.Histochemistry and cell biology · 2018Review
- Psychiatric behaviors associated with cytoskeletal defects in radial neuronal migration.Cellular and molecular life sciences : CMLS · 2017Review
- KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number.Molecular & cellular oncology · 2017Article
- Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor.EMBO reports · 2016Article
- CHFR negatively regulates SIRT1 activity upon oxidative stress.Scientific reports · 2016Article
- KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.Nature communications · 2016Article
- Macromolecular crowding effect is critical for maintaining SIRT1's nuclear localization in cancer cells.Cell cycle (Georgetown, Tex.) · 2016Article
- Review
- Role of the nucleus in apoptosis: signaling and execution.Cellular and molecular life sciences : CMLS · 2015Review
- RBBP4 regulates histone deacetylation and bipolar spindle assembly during oocyte maturation in the mouse.Biology of reproduction · 2015Article
- Article
- Multiplying madly: deacetylases take charge of centrosome duplication and amplification.Cell cycle (Georgetown, Tex.) · 2012Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Centrosome duplication is controlled both negatively and positively by a number of proteins. The activities and stabilities of those regulatory proteins are in many cases controlled by posttranslational modifications. Although acetylation and deacetylation are highly common posttranslational modifications, their roles in the regulation of centrosome duplication had not been closely examined. Here, through focusing on the deacetylases, we investigated the role of acetylation/deacetylation in the regulation of centrosome duplication and induction of abnormal amplification of centrosomes. We found that the deacetylation event negatively controls centrosome duplication and amplification. Of the 18 total known deacetylases (HDAC1-11, SIRT1-7), ten deacetylases possess the activity to suppress centrosome amplification, and their centrosome amplification suppressing activities are strongly associated with their abilities to localize to centrosomes. Among them, HDAC1, HDAC5 and SIRT1 show the highest suppressing activities, but each of them suppresses centrosome duplication and/or amplification with its unique mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.