ArticleDevelopmental biology2012
A cis-element in the Notch1 locus is involved in the regulation of gene expression in interneuron progenitors.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 16 citations in OpenAlex.
- Revisiting the development of cerebellar inhibitory interneurons in the light of single-cell genetic analyses.Histochemistry and cell biology · 2024Review
- Current Advancements in Spinal Cord Injury Research-Glial Scar Formation and Neural Regeneration.Cells · 2023Review
- Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair.Theranostics · 2023Review
- Transcription factors promote neural regeneration after spinal cord injury.Neural regeneration research · 2022Article
- Nkx6.1 enhances neural stem cell activation and attenuates glial scar formation and neuroinflammation in the adult injured spinal cord.Experimental neurology · 2021Article
- Review
- Gsx1 promotes locomotor functional recovery after spinal cord injury.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Article
- VEGF Upregulates EGFR Expression to Stimulate Chemotactic Behaviors in the rMC-1 Model of Müller Glia.Brain sciences · 2020Article
- A novel mouse model for the study of endogenous neural stem and progenitor cells after traumatic brain injury.Experimental neurology · 2020Article
- A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy.Nature communications · 2018Article
- Transcriptional Regulation of Notch1 Expression by Nkx6.1 in Neural Stem/Progenitor Cells during Ventral Spinal Cord Development.Scientific reports · 2016Article
- SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state.PLoS genetics · 2013Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Interneurons comprise approximately one third of the total cortical neurons in the mammalian cerebral cortex. Studies have revealed many details in the generation of this cell type. However, the mechanism that defines interneuron-lineage specific gene expression is not well understood. Gene regulatory elements, e.g., promoters, enhancers, and trans-acting factors, are essential for the proper control of gene expression. Here, we report that a novel evolutionarily conserved cis-element in the second intron of the Notch1 locus plays an important role in regulating gene expression in interneuron progenitors. The spatiotemporal activity of the cis-element in the developing central nervous system (CNS) was determined by both transient reporter expression in the developing chick and a transgenic mouse model. Its activity is well correlated with neurogenesis in both the chick and mouse and restricted to neural progenitor cells in the ganglionic eminence that are fated to differentiate into GABAergic interneurons of the neocortex. We further demonstrate that the cis-element activity requires the binding motif for trans-acting factors Gsh1/Barx2/Brn3. Deletion of this binding motif abolishes reporter gene expression. Together, these data provide new insights into the regulatory mechanisms of interneuron development in the vertebrate CNS.
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