ArticleCurrent biology : CB2012
RhoGEF and positioning of rappaport-like furrows in the early Drosophila embryo.
Article in Current biology : CB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
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- Kinesin-1 patterns Par-1 and Rho signaling at the cortex of syncytial embryos of Drosophila.The Journal of cell biology · 2024Article
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- Centralspindlin-mediated transport of RhoGEF positions the cleavage plane for cytokinesis.Science signaling · 2023Article
- The kinesin-like protein Pavarotti functions noncanonically to regulate actin dynamics.The Journal of cell biology · 2020Article
- Par-1 controls the composition and growth of cortical actin caps duringThe Journal of cell biology · 2019Article
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- Coordination of Embryogenesis by the Centrosome in Drosophila melanogaster.Results and problems in cell differentiation · 2019Review
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- Polo kinase mediates the phosphorylation and cellular localization of Nuf/FIP3, a Rab11 effector.Molecular biology of the cell · 2017Article
- Syndapin promotes pseudocleavage furrow formation by actin organization in the syncytial Drosophila embryo.Molecular biology of the cell · 2016Article
- Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor.Nature communications · 2016Article
- APC2 and Axin promote mitotic fidelity by facilitating centrosome separation and cytoskeletal regulation.Development (Cambridge, England) · 2013Article
- Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo.BioarchitectureArticle
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3 authors at 1 institution in 1 country.
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Abstract
Early Drosophila embryogenesis is characterized by shifting from astral microtubule-based to central spindle-based positioning of cleavage furrows. Before cellularization, astral microtubules determine metaphase furrow position by producing Rappaport-like furrows, which encompass rather than bisect the spindle. Their positioning is explained by our finding that the conserved central spindle components centralspindlin (mKLP1 and RacGAP50C), Polo, and Fascetto (Prc1) localize to the astral microtubule overlap region. These components and the chromosomal passenger complex localize to the central spindle, though no furrow forms there. We identify the maternally supplied RhoGEF2 as a key factor in metaphase furrow positioning. Unlike the zygotic, central spindle-localized RhoGEF (Pebble), RhoGEF2 localizes to metaphase furrows, a function distinct from RhoGEF/Pebble and likely due to the absence of a RacGAP50C binding domain. Accordingly, we find that ectopic activation of Rho GTPase generates furrows perpendicular to the central spindle during syncytial divisions. Whereas metaphase furrow formation is myosin independent, these ectopic furrows, like conventional furrows, require myosin as well as microtubules. These studies demonstrate that early Drosophila embryogenesis is primed to form furrows at either overlapping astral microtubules or the central spindle. We propose that the shift to the latter is driven by a corresponding shift from RhoGEF2 to Pebble in controlling furrow formation.
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