Evidence map›Paper›PMID 23021981›Full record

ReviewThe American journal of pathology2012

Cerebral malaria: we have come a long way.

Henry J Shikani, Brandi D Freeman, Michael P Lisanti, Louis M Weiss, Herbert B Tanowitz, Mahalia S Desruisseaux

Abstract readReview
In one paragraph

Review in The American journal of pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Article
  3. Pharmaceuticals (Basel, Switzerland) · 2024
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Cerebral malaria induced byFrontiers in cellular and infection microbiology · 2022
    Review
  11. Article
  12. Review
  13. Monocyte-derived dendritic cells in malaria.Current opinion in microbiology · 2019
    Review
  14. Review
  15. A retinal model of cerebral malaria.Scientific reports · 2019
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Henry J ShikaniDivision of Parasitology and Tropical Medicine, Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
Brandi D Freeman
Michael P Lisanti
Louis M Weiss
Herbert B Tanowitz
Mahalia S Desruisseaux

Funding

Geographic Medicine and Emerging InfectionsT32AI070117 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2008 to 2023
$5.1M
Molecular NeuropathologyT32NS007098 · NINDS · YESHIVA UNIVERSITY · PI SANTAMBROGIO, LAURA · 1985 to 2015
$5.0M
T. cruzi: pathogenesis modulation by eicosanoidsR01AI076248 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI TANOWITZ, HERBERT BERNARD · 2008 to 2012
$2.3M
Cerebral Malaria: Mechanisms of disease and neurological salvageR01NS069577 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DESRUISSEAUX, MAHALIA S · 2011 to 2015
$1.8M
NIAID NIH HHS AI076248NIAID NIH HHS R01 AI076248NIAID NIH HHS T32 AI070117NINDS NIH HHS NS069577NINDS NIH HHS R01 NS069577NINDS NIH HHS T32 NS007098NINDS NIH HHS T32 NS007098-31Wellcome Trust
6 · The paper itself

Abstract

Despite decades of research, cerebral malaria remains one of the most serious complications of Plasmodium infection and is a significant burden in Sub-Saharan Africa, where, despite effective antiparasitic treatment, survivors develop long-term neurological sequelae. Although much remains to be discovered about the pathogenesis of cerebral malaria, The American Journal of Pathology has been seminal in presenting original research from both human and experimental models. These studies have afforded significant insight into the mechanism of cerebral damage in this devastating disease. The present review highlights information gleaned from these studies, especially in terms of their contributions to the understanding of cerebral malaria.

Indexed as

AnimalsBlood-Brain BarrierHumansInflammationMalaria, CerebralNeuroimagingRadiographyRadionuclide ImagingSignal TransductionVascular Diseases

Identifiers

PMID23021981
PMCPMC3483536

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.