Evidence map›Paper›PMID 23021980›Full record

ReviewTrends in neurosciences2012

Harnessing plasticity to understand learning and treat disease.

Michael P Kilgard

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Music enrichment programs improve the neural encoding of speech in at-risk children.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Trial
  3. Article
  4. Review
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  10. Editorial: The synaptic basis of neuropathology.Frontiers in synaptic neuroscience · 2022
    Article
  11. Review
  12. Review
  13. Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Michael P KilgardThe University of Texas at Dallas, School of Behavioral and Brain Sciences, Richardson, TX 75080, USA. kilgard@utdallas.edu

Funding

Targeted Neural Plasticity for the Treatment of TinnitusR44DC010084 · NIDCD · MICROTRANSPONDER, INC. · PI ENGINEER, NAVZER, KILGARD, MICHAEL P · 2010 to 2011
$2.1M
Animal Model of Speech Sound Processing in AutismR01DC010433 · NIDCD · UNIVERSITY OF TEXAS DALLAS · PI KILGARD, MICHAEL P · 2010 to 2014
$1.4M
Targeted Neural Plasticity for the Treatment of TinnitusR43DC010084 · NIDCD · MICROTRANSPONDER, INC. · PI ENGINEER, NAVZER, KILGARD, MICHAEL P · 2009 to 2009
$360k
Cortical Plasticity and Processing of Speech SoundsR15DC006624 · NIDCD · UNIVERSITY OF TEXAS DALLAS · PI KILGARD, MICHAEL P · 2004 to 2006
$266k
CORTICAL PLASTICITY AND PROCESSING OF COMPLEX STIMULIR03DC004354 · NIDCD · UNIVERSITY OF TEXAS DALLAS · PI KILGARD, MICHAEL P · 2000 to 2002
$153k
NIDCD NIH HHS R01 DC010433NIDCD NIH HHS R01DC010433NIDCD NIH HHS R03 DC004354NIDCD NIH HHS R03DC004354NIDCD NIH HHS R15 DC006624NIDCD NIH HHS R15DC006624NIDCD NIH HHS R43 DC010084NIDCD NIH HHS R43DC010084NIDCD NIH HHS R44 DC010084NIDCD NIH HHS R44DC010084
6 · The paper itself

Abstract

A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies suggest that cortical map plasticity is typically a transient phase that improves learning by increasing the pool of task-relevant responses. Here, I discuss a new perspective on neural plasticity and suggest how plasticity might be targeted to reset dysfunctional circuits. Specifically, a new model is proposed in which map expansion provides a form of replication with variation that supports a Darwinian mechanism to select the most behaviorally useful circuits. Precisely targeted neural plasticity provides a new avenue for the treatment of neurological and psychiatric disorders and is a powerful tool to test the neural mechanisms of learning and memory.

Indexed as

AnimalsBrainCentral Nervous System DiseasesHumansLearningNeuronal Plasticity

Identifiers

PMID23021980
PMCPMC3508154

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.