ArticleImmunity2012
Subsets of nonclonal neighboring CD4+ T cells specifically regulate the frequency of individual antigen-reactive T cells.
Article in Immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- The TCR assigns naive T cells to a preferred lymph node.Science advances · 2024Article
- Multi-variate model of T cell clonotype competition and homeostasis.Scientific reports · 2023Article
- Acute effects of FLT3L treatment on T cells in intact mice.Scientific reports · 2022Article
- Redefining the Foreign Antigen and Self-Driven Memory CD4Frontiers in immunology · 2022Article
- Loss of thymic function promotes EAE relapse in anti-CD52-treated mice.Current research in immunology · 2022Article
- To Remember or to Forget: The Role of Good and Bad Memories in Adoptive T Cell Therapy for Tumors.Frontiers in immunology · 2020Review
- Foxp3Frontiers in immunology · 2019Article
- Role of Cell-Intrinsic and Environmental Age-Related Changes in Altered Maintenance of Murine T Cells in Lymphoid Organs.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Density dependent re-tuning of autoreactive T cells alleviates their pathogenicity in a lymphopenic environment.Immunology letters · 2017Article
- Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection.Cold Spring Harbor perspectives in biology · 2017Review
- PD-1 Controls Tonic Signaling and Lymphopenia-Induced Proliferation of T Lymphocytes.Frontiers in immunology · 2017Article
- Self-reactivity as the necessary cost of maintaining a diverse memory T-cell repertoire.Pathogens and disease · 2016Review
- Enlarged colitogenic T cell population paradoxically supports colitis prevention through the B-lymphocyte-dependent peripheral generation of CD4(+)Foxp3(+) Treg cells.Scientific reports · 2016Article
- Re-examining the Nature and Function of Self-Reactive T cells.Trends in immunology · 2016Review
- How many TCR clonotypes does a body maintain?Journal of theoretical biology · 2016Article
- High-Throughput Analysis of the T Cell Receptor Beta Chain Repertoire in PBMCs from Chronic Hepatitis B Patients with HBeAg Seroconversion.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2016Article
- Self-pMHCII complexes are variably expressed in the thymus and periphery independent of mRNA expression but dependent on the activation state of the APCs.Molecular immunology · 2015Article
- CD8 T cell tolerance to a tumor-associated self-antigen is reversed by CD4 T cells engineered to express the same T cell receptor.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Article
- Profiling the repertoire of T-cell receptor beta-chain variable genes in peripheral blood lymphocytes from subjects who have recovered from acute hepatitis B virus infection.Cellular & molecular immunology · 2014Article
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3 authors at 2 institutions in 1 country.
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Abstract
After an immune response, the expanded population of antigen-specific CD4(+) T cells contract to steady state levels. We have found that the contraction is neither cell-autonomous nor mediated by competition for generic trophic factors, but regulated by relatively rare subsets of neighboring CD4(+) T cells not necessarily of a conventional regulatory T cell lineage. These regulators, referred to as deletors, specifically limit the frequency of particular antigen-specific T cells even though they are not reactive to the same agonist as their targets. Instead, an isolated deletor could outcompete the target for recognition of a shared, nonstimulatory endogenous peptide-MHC ligand. This mechanism was sufficient to prevent even agonist-driven autoimmune disease in a lymphopenic environment. Such a targeted regulation of homeostasis within narrow colonies of T cells with related TCR specificities for subthreshold ligands might help to prevent the loss of unrelated TCRs during multiple responses, preserving the valuable diversity of the repertoire.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.