ReviewJournal of affective disorders2013
Posttraumatic stress disorder, depression, and health-related quality of life in patients with bipolar disorder: review and new data from a multi-site community clinic sample.
Review in Journal of affective disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Quality of life among patients with bipolar disorder in primary care versus community mental health settings.Journal of affective disorders · 2013Trial
- Adaptation of a PTSD intervention for use in primary care in a low-income country: The Brief Relaxation, Education And Trauma HEaling intervention for Ethiopia (BREATHE Ethiopia).SSM. Mental health · 2025Article
- Prevalence and associated factors of depression and posttraumatic stress disorder among trauma patients: multi-centered cross-sectional study.Frontiers in psychiatry · 2025Article
- Plasma and Platelet Brain-Derived Neurotrophic Factor (BDNF) Levels in Bipolar Disorder Patients with Post-Traumatic Stress Disorder (PTSD) or in a Major Depressive Episode Compared to Healthy Controls.International journal of molecular sciences · 2024Article
- Experiences of trauma and psychometric properties of the Life Events Checklist among adults in Uganda.PloS one · 2024Article
- A comparison of symptoms of bipolar and unipolar depression in postpartum women.Journal of affective disorders · 2022Article
- Traumatic events and posttraumatic stress disorder in individuals with severe mental illness in a non-western setting: Data from rural Ethiopia.Psychological trauma : theory, research, practice and policy · 2021Article
- Posttraumatic stress disorder intervention for people with severe mental illness in a low-income country primary care setting: a randomized feasibility trial protocol.Pilot and feasibility studies · 2021Article
- Trauma exposure, depression, suicidal ideation, and alcohol use in people with severe mental disorder in Ethiopia.Social psychiatry and psychiatric epidemiology · 2019Article
- How life stressors influence modifiable lifestyle factors, depressive symptoms, and physical and mental health among Vietnamese older women?BMC psychiatry · 2017Article
- The Turkish Adaptation, Validity, and Reliability of the Internal States Scale.Noro psikiyatri arsivi · 2016Article
- Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers.JAMA psychiatry · 2016Article
- Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction.PloS one · 2013Article
- Mental health care in post-genocide Rwanda: evaluation of a program specializing in posttraumatic stress disorder and substance abuse.Global mental health (Cambridge, England)Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundEvidence suggests that patients with bipolar disorder have an elevated risk for comorbid posttraumatic stress disorder (PTSD) compared to those without a bipolar diagnosis. Although bipolar disorder is associated with decreased health-related quality of life (HRQOL), it is unclear whether comorbid PTSD interacts to affect HRQOL.
methodBaseline data from a multi-site study of patients with bipolar disorder were analyzed. Patient surveys ascertained clinical and demographic information, including physical and mental HRQOL based on the SF-12, mood symptoms (PHQ-9, Internal State Scale), and self-reported co-occurring conditions including PTSD.
resultsOverall (N=384), 44.9% of patients self-reported co-occurring PTSD. Patients with PTSD had lower physical and mental HRQOL scores compared to those without PTSD (mean (SD) for those with and without PTSD, respectively): Mental Component Scale score 30.51 (8.22) and 32.86 (8.35); Physical Component Scale score 35.56 (7.77) and 37.21 (7.20). After adjusting for demographic and clinical factors including mood symptoms, multiple linear regression analyses revealed that PTSD was no longer significantly associated with physical or mental HRQOL; however, depressive symptoms were independently associated with mental HRQOL (Beta -0.63, p<0.01).
conclusionDepressive symptoms may explain the association between PTSD and mental HRQOL. Clinicians working with these patients will want to emphasize treatment of depression as important towards improving HRQOL for this group.
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