ArticleAmerican journal of obstetrics and gynecology2012
Systemic inflammatory stimulation by microparticles derived from hypoxic trophoblast as a model for inflammatory response in preeclampsia.
Article in American journal of obstetrics and gynecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Genetic Association Between Rheumatoid Arthritis and Preeclampsia: A Bidirectional Mendelian Randomization and Bioinformatics Study.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026Article
- Combined analysis of the effects of hypoxia and oxidative stress on DNA methylation and the transcriptome in HTR-8/SVneo trophoblast cells.Journal of cellular and molecular medicine · 2024Article
- Preeclampsia at term: evidence of disease heterogeneity based on the profile of circulating cytokines and angiogenic factors.American journal of obstetrics and gynecology · 2024Article
- The epidermal growth factor receptor in healthy pregnancy and preeclampsia.Journal of molecular endocrinology · 2023Review
- Increased FUN14 domain containing 1 (FUNDC1) ubiquitination level inhibits mitophagy and alleviates the injury in hypoxia-induced trophoblast cells.Bioengineered · 2022Article
- Syncytiotrophoblast Extracellular Vesicles From Late-Onset Preeclampsia Placentae Suppress Pro-Inflammatory Immune Response in THP-1 Macrophages.Frontiers in immunology · 2021Article
- The diagnosis values of serum STAT4 and sEng in preeclampsia.Journal of clinical laboratory analysis · 2020Article
- The Role of Inflammation in the Pathogenesis of Preeclampsia.Mediators of inflammation · 2020Review
- Immunological Role of the Maternal Uterine Microbiome in Pregnancy: Pregnancies Pathologies and Alterated Microbiota.Frontiers in immunology · 2019Review
- Syncytiotrophoblast-Derived Extracellular Vesicles in Pathophysiology of Preeclampsia.Frontiers in physiology · 2019Review
- Extracellular vesicles and their immunomodulatory functions in pregnancy.Seminars in immunopathology · 2018Review
- Placental exosomes: A proxy to understand pregnancy complications.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Review
- The impact of circulating preeclampsia-associated extracellular vesicles on the migratory activity and phenotype of THP-1 monocytic cells.Scientific reports · 2018Article
- Current model systems for the study of preeclampsia.Experimental biology and medicine (Maywood, N.J.) · 2018Review
- Placenta-derived exosomes: potential biomarkers of preeclampsia.International journal of nanomedicine · 2017Review
- Characterization of exosomal release in bovine endometrial intercaruncular stromal cells.Reproductive biology and endocrinology : RB&E · 2016Article
- Preeclampsia and health risks later in life: an immunological link.Seminars in immunopathology · 2016Review
- Placental extracellular vesicles and feto-maternal communication.Cold Spring Harbor perspectives in medicine · 2015Review
- In-vitro study of the effect of anti-hypertensive drugs on placental hormones and angiogenic proteins synthesis in pre-eclampsia.PloS one · 2014Article
- Stimulation of monocytes by placental microparticles involves toll-like receptors and nuclear factor kappa-light-chain-enhancer of activated B cells.Frontiers in immunology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo determine whether trophoblast-derived microparticles can induce different inflammatory responses of the peripheral blood mononuclear cells depending upon the state of trophoblast when the microparticles are generated. STUDY
designA trophoblast-derived cell line (ATCC no. CRL-1584) was cultured under normal or hypoxic conditions. Microparticles were isolated from the cell culture supernatants (microparticles from normal trophoblast; microparticles from hypoxic trophoblast). Peripheral blood mononuclear cells were cultured alone or cocultured with either microparticles from normal trophoblast or microparticles from hypoxic trophoblast.
resultsAfter 48 hours, the peripheral blood mononuclear cells cocultured with microparticles from normal trophoblast released higher concentrations of interleukin-6 than peripheral blood mononuclear cells cultured alone. The peripheral blood mononuclear cells cocultured with microparticles from hypoxic trophoblast showed higher concentration of interleukin-6 and tumor necrosis factor alpha than peripheral blood mononuclear cells cocultured with microparticles from normal trophoblast, after 24 hours and 48 hours.
conclusionMore intense and rapid inflammatory response of peripheral blood mononuclear cells was observed with microparticles from hypoxic trophoblast than with microparticles from normal trophoblast. This difference might explain the exaggerated systemic inflammatory response as a result of placental hypoxia in preeclampsia.
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