ArticleBiological psychiatry2013
Young adults at risk for stimulant dependence show reward dysfunction during reinforcement-based decision making.
Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Neuropsychological Interventions for Decision-Making in Addiction: a Systematic Review.Neuropsychology review · 2019Pooled it
- Acute drug effects differentially predict desire to take dextroamphetamine again for work and recreation.Psychopharmacology · 2021Trial
- Task-dependent increases and decreases of BOLD signal in theory of mind brain regions during strategic social interaction.Frontiers in neural circuits · 2026Article
- Do Adolescents Use Substances to Relieve Uncomfortable Sensations? A Preliminary Examination of Negative Reinforcement among Adolescent Cannabis and Alcohol Users.Brain sciences · 2020Article
- Blunted Frontostriatal Blood Oxygen Level-Dependent Signals Predict Stimulant and Marijuana Use.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Chronotype and Mental Health: Recent Advances.Current psychiatry reports · 2018Review
- Neuroimaging Metrics of Drug and Food Processing in Cocaine-Dependence, as a Function of Psychopathic Traits and Substance Use Severity.Frontiers in human neuroscience · 2018Article
- Insular and cingulate attenuation during decision making is associated with future transition to stimulant use disorder.Addiction (Abingdon, England) · 2017Article
- The roles of valuation and reward processing in cognitive function and psychiatric disorders.Annals of the New York Academy of Sciences · 2017Review
- Prenatal cocaine exposure, illicit-substance use and stress and craving processes during adolescence.Drug and alcohol dependence · 2016Article
- Can Interoception Improve the Pragmatic Search for Biomarkers in Psychiatry?Frontiers in psychiatry · 2016Review
- Bayesian neural adjustment of inhibitory control predicts emergence of problem stimulant use.Brain : a journal of neurology · 2015Article
- Hyperactivation to pleasant interoceptive stimuli characterizes the transition to stimulant addiction.Drug and alcohol dependence · 2015Article
- Take it or leave it: prefrontal control in recreational cocaine users.Translational psychiatry · 2015Article
- Do you feel alright? Attenuated neural processing of aversive interoceptive stimuli in current stimulant users.Psychophysiology · 2015Article
- Attenuated Neural Processing of Risk in Young Adults at Risk for Stimulant Dependence.PloS one · 2015Article
- Cocaine dependent individuals with attenuated striatal activation during reinforcement learning are more susceptible to relapse.Psychiatry research · 2014Article
- Altered neural processing of the need to stop in young adults at risk for stimulant dependence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Striatum and insula dysfunction during reinforcement learning differentiates abstinent and relapsed methamphetamine-dependent individuals.Addiction (Abingdon, England) · 2014Article
- A voxel-based morphometry study of young occasional users of amphetamine-type stimulants and cocaine.Drug and alcohol dependence · 2014Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundWhile stimulant-dependent individuals continue to make risky decisions, in spite of poor outcomes, much less is known about decision-making characteristics of occasional stimulant users (OSU) at risk for developing stimulant dependence. This study examines whether OSU exhibit inefficient learning and execution of reinforced decision-outcome contingencies.
methodsOccasional stimulant users (n = 161) and stimulant-naïve comparison subjects (CTL) (n = 48) performed a Paper Scissors Rock task during functional magnetic resonance imaging. Selecting a particular option was associated with a predetermined probability of winning, which was altered repeatedly to examine neural and behavioral characteristics of reinforced contingencies.
resultsOccasional stimulant users displayed greater anterior insula, inferior frontal gyrus, and dorsal striatum activation than CTL during late trials when contingencies were familiar (as opposed to being learned) in the presence of comparable behavioral performance in both groups. Follow-up analyses demonstrated that during late trials: 1) OSU with high cannabis use displayed greater activation in these brain regions than CTL, whereas OSU with low cannabis use did not differ from the other two groups; and 2) OSU preferring cocaine exhibited greater anterior insula, inferior frontal gyrus, and dorsal striatum activation than CTL and also displayed higher activation in the former two regions than OSU who preferred prescription stimulants.
conclusionsOccasional stimulant users exhibit inefficient resource allocation during the execution of reinforced contingencies that may be a result of additive effects of cocaine and cannabis use. A critical next step is to establish whether this inefficiency predicts transition to stimulant dependence.
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