ReviewLancet (London, England)2012
Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan.
Review in Lancet (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02950506 (Transcranial Direct Current Stimulation and Cognitive Remediation Therapy for Interictal Dysfunction in Epilepsy), which is not on this map. Cited by 159 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transcranial Direct Current Stimulation and Cognitive Remediation Therapy for Interictal Dysfunction in Epilepsy
Who cites it
159 citing papers in PubMed, 4 syntheses or guidelines pooled it, 428 citations in OpenAlex.
- Examining the Effectiveness of Neuropsychological Interventions on Cognition in Patients with Epilepsy: A Systematic Review and Meta-Analysis.Neuropsychology review · 2026Pooled it
- Health-related quality of life and associated factors among epilepsy patients in sub-Saharan Africa: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Antidepressants for people with epilepsy and depression.The Cochrane database of systematic reviews · 2021Pooled it
- Antidepressants for people with epilepsy and depression.The Cochrane database of systematic reviews · 2014Pooled it
- ANT-DBS in epilepsy shows no effect on selected neuropsychiatric tests.Acta neurologica Scandinavica · 2022Trial
- Effectiveness of a Self-Management Program to Improve Cognition and Quality of Life in Epilepsy: A Pragmatic, Randomized, Multicenter Trial.Neurology · 2022Trial
- Neurofeedback impacts cognition and quality of life in pediatric focal epilepsy: An exploratory randomized double-blinded sham-controlled trial.Epilepsy & behavior : E&B · 2019Trial
- Cognitive Side Effects of Antiseizure Medications in Adults with Epilepsy: An Update with a Focus on New Therapeutic Agents.CNS drugs · 2026Review
- Neurocysticercosis in California: Clinical Characteristics and Associated Comorbidities Across the University of California Health System.medRxiv : the preprint server for health sciences · 2026Article
- Sleep disturbance partially mediates the association between depression and epilepsy: data from NHANES 2013-2020.Epilepsy & behavior reports · 2026Article
- Neuropsychological assessment in adult epilepsy: rationale, test selection, and clinical integration across non-surgical care in Italian patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Inflammation modifies breathing phenotype in mice with epilepsy.Journal of neuroinflammation · 2026Article
- Untangling the tangled relationship between cognitive and psychological comorbidities in epilepsy: Bidirectionality and mediation.Epilepsia · 2025Article
- Critical dynamics predicts cognitive performance and provides a common framework for heterogeneous mechanisms impacting cognition.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Association between yoga and multimorbidity: a nationwide study of 279,885 middle-aged and older adults.BMC public health · 2025Article
- Phagocytic Function Analyses of GABBiomedicines · 2025Article
- Epilepsy Therapies Symposium | Do We Really "Outgrow" Seizures?Epilepsy currents · 2024Review
- Annotated interictal discharges in intracranial EEG sleep data and related machine learning detection scheme.Scientific data · 2024Article
- Article
99 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Epilepsy is a common neurological disorder that is complicated by psychiatric, cognitive, and social comorbidities that have become a major target of concern and investigation in view of their adverse effect on the course and quality of life. In this report we define the specific psychiatric, cognitive, and social comorbidities of paediatric and adult epilepsy, their epidemiology, and real life effects; examine the relation between epilepsy syndromes and the risk of neurobehavioural comorbidities; address the lifespan effect of epilepsy on brain neurodevelopment and brain ageing and the risk of neurobehavioural comorbidities; consider the overarching effect of broader brain disorders on both epilepsy and neurobehavioural comorbidities; examine directions of causality and the contribution of selected epilepsy-related characteristics; and outline clinic-friendly screening approaches for these problems and recommended pharmacological, behavioural, and educational interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.