ArticleCell2012
All things to all people.
Article in Cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- MYC as a Target for Cancer Treatment: from Undruggable to Druggable?Targeted oncology · 2025Review
- TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR.International journal of biological sciences · 2022Article
- FOXO transcription factors differ in their dynamics and intra/intermolecular interactions.Current research in structural biology · 2022Article
- Magic roundabout is an endothelial-specific ohnolog of ROBO1 which neo-functionalized to an essential new role in angiogenesis.PloS one · 2019Article
- Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma.Nature genetics · 2018Article
- Modelling of the breadth of expression from promoter architectures identifies pro-housekeeping transcription factors.PloS one · 2018Article
- Review
- Variation-preserving normalization unveils blind spots in gene expression profiling.Scientific reports · 2017Article
- Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis.Oncogene · 2017Article
- c-Myc deregulation induces mRNA capping enzyme dependency.Oncotarget · 2016Article
- MYC-driven aggressive B-cell lymphomas: biology, entity, differential diagnosis and clinical management.Oncotarget · 2015Review
- Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.Biochimica et biophysica acta · 2015Review
- Targeting RNA polymerase I to treat MYC-driven cancer.Oncogene · 2015Review
- Sequence specificity incompletely defines the genome-wide occupancy of Myc.Genome biology · 2014Article
- Control of vertebrate development by MYC.Cold Spring Harbor perspectives in medicine · 2013Review
- Adenovirus E1A oncogene induces rereplication of cellular DNA and alters DNA replication dynamics.Journal of virology · 2013Article
- Review
- Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogaster.PLoS genetics · 2013Article
- Genetic systems to investigate regulation of oncogenes and tumour suppressor genes in Drosophila.Cells · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Myc is an enigma wrapped in a mystery. Attempts to identify Myc target genes, particularly in cancer, have been fraught with dead ends and context-specific functions. Lin et al. and Nie et al. address this conundrum by showing that Myc acts to amplify the output of existing transcriptionally active genes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.