ArticleBMC genomics2012
A comparative analysis of the intestinal metagenomes present in guinea pigs (Cavia porcellus) and humans (Homo sapiens).
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- How informative is the mouse for human gut microbiota research?Disease models & mechanisms · 2015Pooled it
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- Effect of Probiotics on Improving Intestinal Mucosal Permeability and Inflammation after Surgery.Gut and liver · 2025Article
- Bacterial translocation and gut microbiome imbalance in an experimental infection model of legionellosis in guinea pigs.BMC microbiology · 2025Article
- Recent genetic drift in the co-diversified gut bacterial symbionts of laboratory mice.Nature communications · 2025Article
- Big lessons from the littleFrontiers in immunology · 2025Review
- Herbal Extracts Mixed with Essential Oils: A Network Approach for Gastric and Intestinal Motility Disorders.Nutrients · 2024Article
- The Future Exploring of Gut Microbiome-Immunity Interactions: From In Vivo/Vitro Models to In Silico Innovations.Microorganisms · 2024Review
- Recent genetic drift in the co-diversified gut bacterial symbionts of laboratory mice.bioRxiv : the preprint server for biology · 2024Article
- Review
- Unravelling taphono-myths. First large-scale study of histotaphonomic changes and diagenesis in bone from modern surface depositions.PloS one · 2024Article
- Comparative analysis of fasting effects on the cecum microbiome in three guinea pig breeds: Andina, Inti, and Peru.Frontiers in microbiology · 2023Article
- The Analysis of Transcriptomes and Microorganisms Reveals Differences between the Intestinal Segments of Guinea Pigs.Animals : an open access journal from MDPI · 2022Article
- Rational consideration of Akkermansia muciniphila targeting intestinal health: advantages and challenges.NPJ biofilms and microbiomes · 2022Review
- Effects of laboratory domestication on the rodent gut microbiome.ISME communications · 2021Article
- Good to Know: Baseline Data on Feed Intake, Fecal Pellet Output and Intestinal Transit Time in Guinea Pig as a Frequently Used Model in Gastrointestinal Research.Animals : an open access journal from MDPI · 2021Article
- Visualizing the Growth and Division of Rat Gut Bacteria by D-Amino Acid-BasedFrontiers in molecular biosciences · 2021Article
- Active or AutoclavedFrontiers in immunology · 2021Article
- Microbial Diversity and Organic Acid Production of Guinea Pig Faecal Samples.Current microbiology · 2019Article
- The role of the gut microbiota on animal model reproducibility.Animal models and experimental medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGuinea pig (Cavia porcellus) is an important model for human intestinal research. We have characterized the faecal microbiota of 60 guinea pigs using Illumina shotgun metagenomics, and used this data to compile a gene catalogue of its prevalent microbiota. Subsequently, we compared the guinea pig microbiome to existing human gut metagenome data from the MetaHIT project.
resultsWe found that the bacterial richness obtained for human samples was lower than for guinea pig samples. The intestinal microbiotas of both species were dominated by the two phyla Bacteroidetes and Firmicutes, but at genus level, the majority of identified genera (320 of 376) were differently abundant in the two hosts. For example, the guinea pig contained considerably more of the mucin-degrading Akkermansia, as well as of the methanogenic archaea Methanobrevibacter than found in humans. Most microbiome functional categories were less abundant in guinea pigs than in humans. Exceptions included functional categories possibly reflecting dehydration/rehydration stress in the guinea pig intestine. Finally, we showed that microbiological databases have serious anthropocentric biases, which impacts model organism research.
conclusionsThe results lay the foundation for future gastrointestinal research applying guinea pigs as models for humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.