ArticleTissue engineering. Part A2013
Recombinant fibronectin matrix mimetics specify integrin adhesion and extracellular matrix assembly.
Article in Tissue engineering. Part A, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Receptor binding domain of SARS-CoV-2 is a functional αv-integrin agonist.bioRxiv : the preprint server for biology · 2022Article
- The role of integrins in inflammation and angiogenesis.Pediatric research · 2021Review
- Porous polyetheretherketone microcarriers fabricated via hydroxylation together with cell-derived mineralized extracellular matrix coatings promote cell expansion and bone regeneration.Regenerative biomaterials · 2021Article
- Differential alternative splicing between hepatocellular carcinoma with normal and elevated serum alpha-fetoprotein.BMC medical genomics · 2020Article
- Acoustic Fabrication of Collagen-Fibronectin Composite Gels Accelerates Microtissue Formation.Applied sciences (Basel, Switzerland) · 2020Article
- IL-33-induced neutrophil extracellular traps degrade fibronectin in a murine model of bronchopulmonary dysplasia.Cell death discovery · 2020Article
- Article
- Future Research Directions in the Design of Versatile Extracellular Matrix in Tissue Engineering.International neurourology journal · 2018Article
- Serum fibronectin distinguishes the early stages of hepatocellular carcinoma.Scientific reports · 2017Article
- The miR-181d-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling.Cell death and differentiation · 2016Article
- A Small Chimeric Fibronectin Fragment Accelerates Dermal Wound Repair in Diabetic Mice.Advances in wound care · 2016Article
- Extracellular matrix fibronectin mediates an endothelial cell response to shear stress via the heparin-binding, matricryptic RWRPK sequence of FNIII1H.American journal of physiology. Heart and circulatory physiology · 2016Article
- Cooperative effects of fibronectin matrix assembly and initial cell-substrate adhesion strength in cellular self-assembly.Acta biomaterialia · 2016Article
- Extracellular matrix fibronectin initiates endothelium-dependent arteriolar dilatation via the heparin-binding, matricryptic RWRPK sequence of the first type III repeat of fibrillar fibronectin.The Journal of physiology · 2016Article
- Biopolymers and supramolecular polymers as biomaterials for biomedical applications.MRS bulletin · 2015Article
- Utilizing Fibronectin Integrin-Binding Specificity to Control Cellular Responses.Advances in wound care · 2015Review
- Fibronectin Interaction and Enhancement of Growth Factors: Importance for Wound Healing.Advances in wound care · 2015Review
- Opposing effects of collagen I and vitronectin on fibronectin fibril structure and function.Matrix biology : journal of the International Society for Matrix Biology · 2014Article
- Propolis modulates fibronectin expression in the matrix of thermal injury.BioMed research international · 2014Article
- Fibronectin matrix mimetics promote full-thickness wound repair in diabetic mice.Tissue engineering. Part A · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tissue engineering seeks to create functional tissues and organs by integrating natural or synthetic scaffolds with bioactive factors and cells. Creating biologically active scaffolds that support key aspects of tissue regeneration, including the re-establishment of a functional extracellular matrix (ECM), is a challenge currently facing this field. During tissue repair, fibronectin is converted from an inactive soluble form into biologically active ECM fibrils through a cell-dependent process. ECM fibronectin promotes cell processes critical to tissue regeneration and regulates the deposition and organization of other ECM proteins. We previously developed biomimetics of ECM fibronectin by directly coupling the heparin-binding fragment of the first type III repeat of fibronectin (FNIII1H) to the integrin-binding repeats (FNIII8-10). As adhesive substrates, fibronectin matrix mimetics promote cell growth, migration, and contractility through a FNIII1H-dependent mechanism. Here, we analyzed fibronectin matrix mimetic variants designed to include all or part of the integrin-binding domain for their ability to support new ECM assembly. We found that specific modifications of the integrin-binding domain produced adhesive substrates that selectively engage different integrin receptors to, in turn, regulate the amount of fibronectin and collagen deposited into the ECM. The ability of fibronectin matrix mimetics to direct cell-substrate interactions and regulate ECM assembly makes them promising candidates for use as bioactive surfaces, where precise control over integrin-binding specificity and ECM deposition are required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.