ArticleScience (New York, N.Y.)2012
Mutations in the neverland gene turned Drosophila pachea into an obligate specialist species.
Article in Science (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 92 citations in OpenAlex.
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- Loss of Sterol Biosynthesis in Economically Important Plant Pests and Pathogens: A Review of a Potential Target for Pest Control.Biomolecules · 2024Review
- High-throughput and genome-scale targeted mutagenesis using CRISPR in a nonmodel multicellular organism,Genome research · 2024Article
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- Transcriptional Regulators of Ecdysteroid Biosynthetic Enzymes and Their Roles in Insect Development.Frontiers in physiology · 2022Review
- Integrated miRNA and transcriptome profiling to explore the molecular determinism of convergent adaptation to corn in two lepidopteran pests of agriculture.BMC genomics · 2021Article
- DrosoPhyla: Resources for Drosophilid Phylogeny and Systematics.Genome biology and evolution · 2021Article
- Pollen sterols are associated with phylogeny and environment but not with pollinator guilds.The New phytologist · 2021Article
- Male genital lobe morphology affects the chance to copulate in Drosophila pachea.BMC ecology and evolution · 2021Article
- Comparative analysis of diet-associated responses in two rice planthopper species.BMC genomics · 2020Article
- Genetic Divergence of TwoInsects · 2020Article
- Article
- Evolution of Reproductive Behavior.Genetics · 2020Review
- Expression, Purification, Refolding, and Characterization of aFrontiers in bioengineering and biotechnology · 2020Article
- Generalized host-plant feeding can hide sterol-specialized foraging behaviors in bee-plant interactions.Ecology and evolution · 2020Article
- Review
- Reproductive Capacity Evolves in Response to Ecology through Common Changes in Cell Number in Hawaiian Drosophila.Current biology : CB · 2019Article
- Repeated evolution of asymmetric genitalia and right-sided mating behavior in the Drosophila nannoptera species group.BMC evolutionary biology · 2019Article
- Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Most living species exploit a limited range of resources. However, little is known about how tight associations build up during evolution between such specialist species and the hosts they use. We examined the dependence of Drosophila pachea on its single host, the senita cactus. Several amino acid changes in the Neverland oxygenase rendered D. pachea unable to transform cholesterol into 7-dehydrocholesterol (the first reaction in the steroid hormone biosynthetic pathway in insects) and thus made D. pachea dependent on the uncommon sterols of its host plant. The neverland mutations increase survival on the cactus's unusual sterols and are in a genomic region that faced recent positive selection. This study illustrates how relatively few genetic changes in a single gene may restrict the ecological niche of a species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.