ReviewClinical & developmental immunology2012
Glutamine randomized studies in early life: the unsolved riddle of experimental and clinical studies.
Review in Clinical & developmental immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Macrophage metabolism reprogramming in sepsis: Pathogenesis and therapeutic implications (Review).International journal of molecular medicine · 2026Review
- Identification of potential biomarkers in malnutrition children with severity byEuropean journal of nutrition · 2023Article
- Ex Vivo Evaluation of Glutamine Treatment in Sepsis and Trauma in a Human Peripheral Blood Mononuclear Cells Model.Nutrients · 2023Article
- Oxidant/Antioxidant Status Is Impaired in Sepsis and Is Related to Anti-Apoptotic, Inflammatory, and Innate Immunity Alterations.Antioxidants (Basel, Switzerland) · 2022Article
- Concentrating human milk: an innovative point-of-care device designed to increase human milk feeding options for preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Short Communication: Differences in Levels of Free Amino Acids and Total Protein in Human Foremilk and Hindmilk.Nutrients · 2018Article
- The Metabolic Response to Stress and Infection in Critically Ill Children: The Opportunity of an Individualized Approach.Nutrients · 2017Review
- Polymyxin B hemoperfusion in septic shock: nothing overmuch (Meden Agan)!Journal of thoracic disease · 2017Article
- Alterations in metabolic patterns in critically ill patients-is there need of action?European journal of clinical nutrition · 2017Article
- Early Administration of Glutamine Protects Cardiomyocytes from Post-Cardiac Arrest Acidosis.BioMed research international · 2016Article
- Experimental treatments for mitochondrial dysfunction in sepsis: A narrative review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Review
- Glutamine may repress the weak LPS and enhance the strong heat shock induction of monocyte and lymphocyte HSP72 proteins but may not modulate the HSP72 mRNA in patients with sepsis or trauma.BioMed research international · 2015Article
- Enteral L-Arginine and Glutamine Supplementation for Prevention of NEC in Preterm Neonates.International journal of pediatrics · 2015Article
- Heat shock protein 72 expressing stress in sepsis: unbridgeable gap between animal and human studies--a hypothetical "comparative" study.BioMed research international · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamine may have benefits during immaturity or critical illness in early life but its effects on outcome end hardpoints are controversial. Our aim was to review randomized studies on glutamine supplementation in pups, infants, and children examining whether glutamine affects outcome. Experimental work has proposed various mechanisms of glutamine action but none of the randomized studies in early life showed any effect on mortality and only a few showed some effect on inflammatory response, organ function, and a trend for infection control. Although apparently safe in animal models (pups), premature infants, and critically ill children, glutamine supplementation does not reduce mortality or late onset sepsis, and its routine use cannot be recommended in these sensitive populations. Large prospectively stratified trials are needed to better define the crucial interrelations of "glutamine-heat shock proteins-stress response" in critical illness and to identify the specific subgroups of premature neonates and critically ill infants or children who may have a greater need for glutamine and who may eventually benefit from its supplementation. The methodological problems noted in the reviewed randomized experimental and clinical trials should be seriously considered in any future well-designed large blinded randomized controlled trial involving glutamine supplementation in critical illness.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.