ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2012
Risk for cervical intraepithelial neoplasia grade 3 or worse in relation to smoking among women with persistent human papillomavirus infection.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
- In-clinic Versus Online Recruitment of Women With a History of Cervical Intraepithelial Neoplasia or Cervical Cancer to a Smoking Cessation Trial: A Post hoc Comparison of Participant Characteristics, Study Retention, and Cessation Outcomes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Trial
- The Association between Smoking and Anal Human Papillomavirus in the HPV Infection in Men Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Article
- Real-World Effectiveness of Human Papillomavirus Vaccination Against Cervical Cancer.Journal of the National Cancer Institute · 2021Article
- Smoking cessation advice after cervical screening: a qualitative interview study of acceptability in Dutch primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019Article
- Association between patient-reported HIV status and provider recommendation for screening in an opportunistic cervical Cancer screening setting in Jos, Nigeria.BMC health services research · 2018Article
- Impact of HPV vaccination on outcome of cervical cytology screening in Denmark-A register-based cohort study.International journal of cancer · 2018Article
- Investigation of differentially-expressed microRNAs and genes in cervical cancer using an integrated bioinformatics analysis.Oncology letters · 2017Article
- Comorbidities of Atopic Dermatitis: Beyond Rhinitis and Asthma.Current dermatology reports · 2017Review
- Multiple preinvasive and invasive HPV-related lesions of the anogenital tract in a female patient with HIV infection: A case report.Medicine · 2017Article
- Nucleotide Excision Repair Gene ERCC2 and ERCC5 Variants Increase Risk of Uterine Cervical Cancer.Cancer research and treatment · 2016Article
- Cell mediated immunity against HPV16 E2, E6 and E7 peptides in women with incident CIN and in constantly HPV-negative women followed-up for 10-years.Journal of translational medicine · 2015Article
- Identification of differentially-expressed genes by DNA methylation in cervical cancer.Oncology letters · 2015Article
- Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up.British journal of cancer · 2013Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSmoking has been associated with cervical cancer. We examined whether smoking increases the risk for high-grade cervical lesions in women with high-risk human papillomavirus (HPV) infection.
methodsIn a population-based cohort study, 8,656 women underwent a structured interview, and subsequently cervical cells were obtained for HPV DNA testing. Women with high-risk HPV infection and no prevalent cervical disease at baseline (n = 1,353) were followed through the Pathology Data Bank for cervical lesions for up to 13 years. Separate analyses of women with persistent high-risk HPV infection (n = 312) were also conducted. HRs for a diagnosis of cervical intraepithelial neoplasia grade 3 or worse/high-grade squamous intraepithelial lesions or worse (CIN3+) and the corresponding 95% confidence intervals (CI) were calculated in the two groups.
resultsAmong high-risk HPV-positive women, an increased risk for CIN3+ was associated with long-term smoking (≥10 years) and heavy smoking (≥20 cigarettes/d). In the subgroup of women with persistent HPV infection, heavy smoking was also associated with a statistically significantly higher risk for CIN3+ than never smoking (HR, 1.85; 95% CI, 1.05-3.22, adjusted for length of schooling, parity, and HPV type at baseline). The average number of cervical cytology screening tests per year during follow-up did not explain the differences in risk in relation to smoking (P = 0.4).
conclusionsSmoking is associated with an increased risk for subsequent high-grade cervical lesions in women with persistent high-risk HPV infection. IMPACT: Our study adds to the understanding of the role of smoking in the natural history of HPV and cervical carcinogenesis.
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