ArticleCell death and differentiation2013
Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila.
Article in Cell death and differentiation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- The histone demethylase Kdm5 controls Hid-induced cell death inFrontiers in cell death · 2024Article
- Signaling plasticity in the integrated stress response.Frontiers in cell and developmental biology · 2023Review
- Article
- An efficient and multiple target transgenic RNAi technique with low toxicity in Drosophila.Nature communications · 2018Article
- Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex.Science signaling · 2018Article
- Modelling Cooperative Tumorigenesis inBioMed research international · 2018Review
- Hedgehog signalling is required for cell survival in Drosophila wing pouch cells.Scientific reports · 2017Article
- Clonal cooperativity in heterogenous cancers.Seminars in cell & developmental biology · 2017Review
- Your neighbours matter - non-autonomous control of apoptosis in development and disease.Cell death and differentiation · 2016Review
- Functional Interaction between HEXIM and Hedgehog Signaling during Drosophila Wing Development.PloS one · 2016Article
- Neural stem cell progeny regulate stem cell death in a Notch and Hox dependent manner.Cell death and differentiation · 2015Article
- Suppression of induced but not developmental apoptosis in Drosophila by Ayurvedic Amalaki Rasayana and Rasa-Sindoor.Journal of biosciences · 2015Article
- Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer.Oncotarget · 2015Article
- Multiple mechanisms modulate distinct cellular susceptibilities toward apoptosis in the developing Drosophila eye.Developmental cell · 2014Article
- Hedgehog is a positive regulator of FGF signalling during embryonic tracheal cell migration.PloS one · 2014Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Hedgehog (Hh) signaling is important for development and homeostasis in vertebrates and invertebrates. Ligand-independent, deregulated Hh signaling caused by loss of negative regulators such as Patched causes excessive cell proliferation, leading to overgrowth in Drosophila and tumors in humans, including basal-cell carcinoma and medulloblastoma. We show that in Drosophila deregulated Hh signaling also promotes cell survival by increasing the resistance to apoptosis. Surprisingly, cells with deregulated Hh activity do not protect themselves from apoptosis; instead, they promote cell survival of neighboring wild-type cells. This non-cell autonomous effect is mediated by Hh-induced Notch signaling, which elevates the protein levels of Drosophila inhibitor of apoptosis protein-1 (Diap-1), conferring resistance to apoptosis. In summary, we demonstrate that deregulated Hh signaling not only promotes proliferation but also cell survival of neighboring cells. This non-cell autonomous control of apoptosis highlights an underappreciated function of deregulated Hh signaling, which may help to generate a supportive micro-environment for tumor development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.