Evidence map›Paper›PMID 23018377›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2013

Associations between genital tract infections, genital tract inflammation, and cervical cytobrush HIV-1 DNA in US versus Kenyan women.

Caroline Mitchell, Jennifer E Balkus, Jennifer McKernan-Mullin, Susan E Cohn, Amneris E Luque, Christina Mwachari, Craig R Cohen, Robert Coombs, Lisa M Frenkel, Jane Hitti

Abstract readComparative Study
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Levels of Genital Tract Defensins and Cytokines Differ between HIV-Uninfected US and African Women.American journal of reproductive immunology (New York, N.Y. : 1989) · 2015
    Trial
  3. Article
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  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Caroline MitchellDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA 98104, USA. camitch@uw.edu
Jennifer E Balkus
Jennifer McKernan-Mullin
Susan E Cohn
Amneris E Luque
Christina Mwachari
Craig R Cohen
Robert Coombs
Lisa M Frenkel
Jane Hitti
University of Washington · USBeijing Obstetrics and Gynecology Hospital · CNKenya Medical Research Institute · KENorthwestern University · USSeattle Children's Hospital · USUniversity of California, San Francisco · USUniversity of Rochester · US

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
WOMEN'S REPRODUCTIVE HEALTH RESEARCH CAREER DEVELOPMENTK12HD001264 · NICHD · UNIVERSITY OF WASHINGTON · PI Barbara Ann Goff · 1998 to 2026
$8.6M
HIV SHEDDING AND EVOLUTIONP01HD040540 · NICHD · UNIVERSITY OF WASHINGTON · PI COOMBS, ROBERT W. · 2001 to 2006
$7.5M
Effect of Lactobacillus on genital HIV-1 RNA and DNA shedding in womenR21AI080439 · NIAID · UNIVERSITY OF WASHINGTON · PI HITTI, JANE E · 2008 to 2010
$870k
NIAID NIH HHS 1R21AI080439-01A1NIAID NIH HHS P30 AI027763NIAID NIH HHS R21 AI080439NICHD NIH HHS HD-01-264NICHD NIH HHS K12 HD001264NICHD NIH HHS P01 HD040540NICHD NIH HHS P01HD40540
6 · The paper itself

Abstract

Cervical shedding of HIV-1 DNA may influence HIV-1 sexual transmission. HIV-1 DNA was detected in 250 (80%) of 316 and 207 (79%) of 259 cervical cytobrush specimens from 56 US and 80 Kenyan women, respectively. Plasma HIV-1 RNA concentration was associated with increased HIV-1 DNA shedding among US and Kenyan women. Kenyan women had higher cervicovaginal concentrations of proinflammatory interleukins (IL)-1β, IL-6, IL-8, and anti-inflammatory secretory leukocyte protease inhibitor compared with US women (all P < 0.01). HIV-1 DNA shedding was associated with increased concentrations of IL-1β and IL-6 and lower secretory leukocyte protease inhibitor among US women but not Kenyan women.

Indexed as

AdultAnti-Retroviral AgentsCD4 Lymphocyte CountCervix UteriCytomegalovirus InfectionsDNA, ViralFemaleHerpes GenitalisHIV-1HIV InfectionsHumansInterleukin-1Interleukin-1betaInterleukin-8KenyaMiddle AgedAnti-Retroviral AgentsDNA, ViralInterleukin-1Interleukin-1betaInterleukin-8RNA, Viral

Identifiers

PMID23018377
PMCPMC3549039
OpenAlexW2015554019

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.