Evidence map›Paper›PMID 23018094›Full record

ArticleBioorganic & medicinal chemistry2012

Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand.

Alia H Clark, John D McCorvy, Jason M Conley, Whitney K Williams, Markondaiah Bekkam, Val J Watts, David E Nichols

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Conformation-driven C3-C(Nature catalysis · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alia H ClarkDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy and Integrative Neuroscience Program, Purdue University, West Lafayette, IN 47907, USA.
John D McCorvy
Jason M Conley
Whitney K Williams
Markondaiah Bekkam
Val J Watts
David E Nichols

Funding

DEVELOPMENT OF POTENTIALLY SELECTIVE DOPAMINE AGONISTSR01MH042705 · NIMH · PURDUE UNIVERSITY WEST LAFAYETTE · PI NICHOLS, DAVID E · 1987 to 2010
$3.4M
D2 RECEPTOR-INDUCED SENSITIZATION OF ADENYLATE CYCLASER01MH060397 · NIMH · PURDUE UNIVERSITY WEST LAFAYETTE · PI DESSAUER, CARMEN W., WATTS, VAL J · 2000 to 2012
$3.0M
NIMH NIH HHS MH42705NIMH NIH HHS MH60397NIMH NIH HHS R01 MH042705NIMH NIH HHS R01 MH060397
6 · The paper itself

Abstract

This work describes the identification of a novel class of octahydrobenzo[f]quinolines as dopamine D(3)-selective full agonists. We developed a facile method that utilizes Suzuki coupling for easy incorporations of various substituted pendant rings into the scaffold. A small focused library of octahydrobenzo[f]quinolines 5 was synthesized, and these compounds demonstrated at least 14-fold D(2)-like selectivity over D(1) in native porcine striatal tissue. Furthermore, n-propyl analog 5f was found to be a high affinity (K(i)=1.1 nM) D(3) dopamine full agonist with 145-fold selectivity over the D(2) receptor and about 840-fold selectivity over the D(1) receptor.

Indexed as

Binding, CompetitiveCells, CulturedDose-Response Relationship, DrugHEK293 CellsHumansLigandsModels, MolecularMolecular ConformationQuinolinesReceptors, Dopamine D3Structure-Activity RelationshipLigandsoctahydrobenzo(f)quinolineQuinolinesReceptors, Dopamine D3

Identifiers

PMID23018094
PMCPMC3505999

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.