Evidence map›Paper›PMID 23017731›Full record

ReviewTrends in immunology2013

Invariant natural killer T cells as sensors and managers of inflammation.

Luc Van Kaer, Vrajesh V Parekh, Lan Wu

Abstract readReview
In one paragraph

Review in Trends in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Innate and Innate-like Effector Lymphocytes in Health and Disease.Journal of immunology (Baltimore, Md. : 1950) · 2022
    Review
  6. Article
  7. Article
  8. Preferential and persistent impact of acute HIV-1 infection on CD4Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Review
  10. Review
  11. Review
  12. Preface: Unconventional T Cells in Health and Disease.Critical reviews in immunology · 2021
    Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Luc Van KaerDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. luc.van.kaer@vanderbilt.edu
Vrajesh V Parekh
Lan Wu

Funding

Mechanisms and consequences of iNKT cell anergyR01AI070305 · NIAID · VANDERBILT UNIVERSITY · PI VAN KAER, LUC · 2007 to 2011
$1.9M
Modulation of chronic vascular inflammation by iNKT cellsR01HL089667 · NHLBI · VANDERBILT UNIVERSITY · PI VAN KAER, LUC · 2009 to 2012
$1.5M
Glycolipid-Reactive NKT Cells, Obesity and Insulin ResistanceR01DK081536 · NIDDK · VANDERBILT UNIVERSITY · PI VAN KAER, LUC, WU, LAN · 2010 to 2013
$1.3M
Modulation of EAE with ligand-activated NKT cellsR01NS044044 · NINDS · VANDERBILT UNIVERSITY · PI VAN KAER, LUC · 2002 to 2005
$1.3M
NHLBI NIH HHS R01 HL089667NIAID NIH HHS R01 AI070305NIDDK NIH HHS R01 DK081536NINDS NIH HHS R01 NS044044
6 · The paper itself

Abstract

Invariant natural killer T (iNKT) cells are a subset of innate-like lymphocytes that recognize glycolipid antigens bound by the major histocompatibility complex (MHC)-class-I-related protein CD1d. iNKT cells are activated early during a variety of infections and inflammatory diseases and contribute to the subsequent development of adaptive immune responses. Consequently, iNKT cells play a critical role in the development and resolution of inflammatory diseases and represent attractive targets for the development of immunotherapies. Recent studies have provided important insight into the mechanisms by which iNKT cells become activated in response to diverse inflammatory stimuli. These new findings should be instrumental to promote the immunomodulatory properties of iNKT cells for treatment of inflammatory diseases.

Indexed as

Lymphocyte ActivationAnimalsAntigens, CD1dHumansImmunotherapyInfectionsInflammationMiceNatural Killer T-CellsAntigens, CD1d

Identifiers

PMID23017731
PMCPMC3615427

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.