ArticleNeuropsychologia2012
Reading without the left ventral occipito-temporal cortex.
Article in Neuropsychologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 72 citations in OpenAlex.
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- Cross-sectional and longitudinal changes in category selectivity in visual cortex following pediatric cortical resection.Communications biology · 2025Article
- Tracking novel visual word learning via different methods with an original FPVS-EEG approach.Frontiers in human neuroscience · 2025Article
- Constraining current neuroanatomical models of reading: the view from Arabic.Brain structure & function · 2024Review
- Degeneracy in the neurological model of auditory speech repetition.Communications biology · 2023Article
- The elusive metric of lesion load.Brain structure & function · 2023Review
- Dyslexia: Causes and Concomitant Impairments.Brain sciences · 2023Review
- Converting sounds to meaning with ventral semantic language networks: integration of interdisciplinary data on brain connectivity, direct electrical stimulation and clinical disconnection syndromes.Brain structure & function · 2022Review
- Is Developmental Dyslexia Due to a Visual and Not a Phonological Impairment?Brain sciences · 2021Review
- Simulating lesion-dependent functional recovery mechanisms.Scientific reports · 2021Article
- Reading Increases the Compositionality of Visual Word Representations.Psychological science · 2019Article
- Dissociating the functions of superior and inferior parts of the left ventral occipito-temporal cortex during visual word and object processing.NeuroImage · 2019Article
- A lesion and connectivity-based hierarchical model of chronic aphasia recovery dissociates patients and healthy controls.NeuroImage. Clinical · 2019Article
- Characterising neural plasticity at the single patient level using connectivity fingerprints.NeuroImage. Clinical · 2019Article
- The effects of lesion and treatment-related recovery on functional network modularity in post-stroke dysgraphia.NeuroImage. Clinical · 2019Article
- Left frontotemporal effective connectivity during semantic feature judgments in patients with chronic aphasia and age-matched healthy controls.Cortex; a journal devoted to the study of the nervous system and behavior · 2018Article
- Selective visual representation of letters and words in the left ventral occipito-temporal cortex with intracerebral recordings.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Interpreting and Utilising Intersubject Variability in Brain Function.Trends in cognitive sciences · 2018Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
The left ventral occipito-temporal cortex (LvOT) is thought to be essential for the rapid parallel letter processing that is required for skilled reading. Here we investigate whether rapid written word identification in skilled readers can be supported by neural pathways that do not involve LvOT. Hypotheses were derived from a stroke patient who acquired dyslexia following extensive LvOT damage. The patient followed a reading trajectory typical of that associated with pure alexia, re-gaining the ability to read aloud many words with declining performance as the length of words increased. Using functional MRI and dynamic causal modelling (DCM), we found that, when short (three to five letter) familiar words were read successfully, visual inputs to the patient's occipital cortex were connected to left motor and premotor regions via activity in a central part of the left superior temporal sulcus (STS). The patient analysis therefore implied a left hemisphere "reading-without-LvOT" pathway that involved STS. We then investigated whether the same reading-without-LvOT pathway could be identified in 29 skilled readers and whether there was inter-subject variability in the degree to which skilled reading engaged LvOT. We found that functional connectivity in the reading-without-LvOT pathway was strongest in individuals who had the weakest functional connectivity in the LvOT pathway. This observation validates the findings of our patient's case study. Our findings highlight the contribution of a left hemisphere reading pathway that is activated during the rapid identification of short familiar written words, particularly when LvOT is not involved. Preservation and use of this pathway may explain how patients are still able to read short words accurately when LvOT has been damaged.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.