ArticleEnvironmental health perspectives2012
Early zebrafish embryogenesis is susceptible to developmental TDCPP exposure.
Article in Environmental health perspectives, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 169 citations in OpenAlex.
- Article
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- Developmental neurotoxicity of organophosphate flame retardants (OPFRs): risks to human health and ecosystems.Archives of toxicology · 2025Review
- Perfluorooctanesulfonamide-induced epiboly delay is associated with decreased ATP production within zebrafish embryos.Ecotoxicology and environmental safety · 2025Article
- Dermal Exposure to Organophosphorus Compounds in Home Video Game Controllers.Environment & health (Washington, D.C.) · 2025Article
- Tris(1,3-dichloro-2-propyl) phosphate disrupts cellular metabolism within human embryonic kidney (HEK293) cells.Journal of hazardous materials · 2024Article
- Exposure to tris (1,3-dichloro-2-propyl) phosphate affects the embryonic cardiac development ofHeliyon · 2024Article
- Elucidating the toxicity mechanisms of organophosphate esters by adverse outcome pathway network.Archives of toxicology · 2024Article
- Spleen Toxicity of Organophosphorus Flame Retardant TDCPP in Mice and the Related Mechanisms.Toxics · 2023Article
- Triphenyl phosphate-induced pericardial edema in zebrafish embryos is dependent on the ionic strength of exposure media.Environment international · 2023Article
- Associations of gestational exposure to organophosphate esters with gestational age and neonatal anthropometric measures: The HOME study.Environmental pollution (Barking, Essex : 1987) · 2023Article
- Childhood urinary organophosphate esters and cognitive abilities in a longitudinal cohort study.Environmental research · 2022Article
- Organophosphate esters cause thyroid dysfunction via multiple signaling pathways in zebrafish brain.Environmental science and ecotechnology · 2022Article
- Rapid and Efficient Spatiotemporal Monitoring of Normal and Aberrant Cytosine Methylation within Intact Zebrafish Embryos.Journal of visualized experiments : JoVE · 2022Article
- Tris(1,3-dichloro-2-propyl) phosphate disrupts the trajectory of cytosine methylation within developing zebrafish embryos.Environmental research · 2022Article
- Organelle specific fluorescent phenomics and transcriptomic profiling to evaluate cellular response to tris(1,3 dichloro 2 propyl)phosphate.Scientific reports · 2022Article
- Occurrence, Distribution, and Risk of Organophosphate Flame Retardants in Sediments from Jiulong River Estuary and Adjacent Western Taiwan Strait, China.International journal of environmental research and public health · 2022Article
- Prenatal exposure to a mixture of organophosphate esters and intelligence among 8-year-old children of the HOME Study.Neurotoxicology · 2021Article
- Developmental phenotypic and transcriptomic effects of exposure to nanomolar levels of metformin in zebrafish.Environmental toxicology and pharmacology · 2021Article
- Predictive Capability of QSAR Models Based on the CompTox Zebrafish Embryo Assays: An Imbalanced Classification Problem.Molecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChlorinated phosphate esters (CPEs) are widely used as additive flame retardants for low-density polyurethane foams and have frequently been detected at elevated concentrations within indoor environmental media.
objectivesTo begin characterizing the potential toxicity of CPEs on early vertebrate development, we examined the developmental toxicity of four CPEs used in polyurethane foam: tris(1,3-dichloro-2-propyl) phosphate (TDCPP), tris(2-chloroethyl) phosphate (TCEP), tris(1-chloro-2-propyl) phosphate (TCPP), and 2,2-bis(chloromethyl)propane-1,3-diyl tetrakis(2-chlorethyl) bis(phosphate) (V6).
methodsUsing zebrafish as a model for vertebrate embryogenesis, we first screened the potential teratogenic effects of TDCPP, TCEP, TCPP, and V6 using a developmental toxicity assay. Based on these results, we focused on identification of susceptible windows of developmental TDCPP exposure as well as evaluation of uptake and elimination of TDCPP and bis(1,3-dichloro-2-propyl)phosphate (BDCPP, the primary metabolite) within whole embryos. Finally, because TDCPP-specific genotoxicity assays have, for the most part, been negative in vivo and because zygotic genome remethylation is a key biological event during cleavage, we investigated whether TDCPP altered the status of zygotic genome methylation during early zebrafish embryogenesis.
resultsOverall, our findings suggest that the cleavage period during zebrafish embryogenesis is susceptible to TDCPP-induced delays in remethylation of the zygotic genome, a mechanism that may be associated with enhanced developmental toxicity following initiation of TDCPP exposure at the start of cleavage.
conclusionsOur results suggest that further research is needed to better understand the effects of a widely used and detected CPE within susceptible windows of early vertebrate development.
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