ArticleJournal of neurochemistry2013
Role of TrkB expression in rat adrenal gland during acute immobilization stress.
Article in Journal of neurochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Effect of Electrical Muscle Stimulation and Resistance Exercise Intervention on Physical and Brain Function in Middle-Aged and Older Women.International journal of environmental research and public health · 2022Trial
- Brain-derived neurotrophic factor is related to stress and chewing in saliva and salivary glands.The Japanese dental science review · 2020Review
- Exploring the anti-stress effects of imatinib and tetrabenazine in cold-water immersion-induced acute stress in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Neuromuscular electrical stimulation increases serum brain-derived neurotrophic factor in humans.Experimental brain research · 2019Article
- Hypoxia-regulated catecholamine secretion in chromaffin cells.Cell and tissue research · 2018Review
- Salivary Gland Derived BDNF Overexpression in Mice Exerts an Anxiolytic Effect.International journal of molecular sciences · 2017Article
- Comment on "Comparison of Electroacupuncture in Restrained and Unrestrained Rat Models".Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Genetic association of the transcription of neuroplasticity-related genes and variation in stress-coping style.Brain and behavior · 2015Article
- Enhanced BDNF signalling following chronic hypoxia potentiates catecholamine release from cultured rat adrenal chromaffin cells.The Journal of physiology · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of tyrosine receptor kinase B (TrkB), a receptor for brain-derived neurotrophic factor (BDNF), is markedly elevated in the adrenal medulla during immobilization stress. Catecholamine release was confirmed in vitro by stimulating chromaffin cells with recombinant BDNF. We investigated the role of TrkB and the localization of BDNF in the adrenal gland during immobilization stress for 60 min. Blood catecholamine levels increased after stimulation with TrkB expressed in the adrenal medulla during 60-min stress; however, blood catecholamine levels did not increase in adrenalectomized rats. Furthermore, expression of BDNF mRNA and protein was detected in the adrenal medulla during 60-min stress. Similarly, in rats undergoing sympathetic nerve block with propranolol, BDNF mRNA and protein were detected in the adrenal medulla during 60-min stress. These results suggest that signal transduction of TrkB in the adrenal medulla evokes catecholamine release. In addition, catecholamine release was evoked by both the hypothalamic-pituitary-adrenal axis and autocrine signaling by BDNF in the adrenal gland. BDNF-TrkB interaction may play a role in a positive feedback loop in the adrenal medulla during immobilization stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.