ArticleJournal of cognitive neuroscience2012
Columnar processing in primate pFC: evidence for executive control microcircuits.
Article in Journal of cognitive neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- The modular organization of the cerebral cortex: Evolutionary significance and possible links to neurodevelopmental conditions.The Journal of comparative neurology · 2019Review
- A cognitive prosthesis for memory facilitation by closed-loop functional ensemble stimulation of hippocampal neurons in primate brain.Experimental neurology · 2017Article
- What Is the Evidence for Inter-laminar Integration in a Prefrontal Cortical Minicolumn?Frontiers in neuroanatomy · 2017Article
- The Structural and Functional Organization of Cognition.Frontiers in human neuroscience · 2016Article
- Prefrontal cortical recordings with biomorphic MEAs reveal complex columnar-laminar microcircuits for BCI/BMI implementation.Journal of neuroscience methods · 2015Article
- Distinguishing cognitive state with multifractal complexity of hippocampal interspike interval sequences.Frontiers in systems neuroscience · 2015Article
- Disruption of columnar and laminar cognitive processing in primate prefrontal cortex following cocaine exposure.Frontiers in systems neuroscience · 2015Article
- Distinct neuronal interactions in anterior inferotemporal areas of macaque monkeys during retrieval of object association memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Prefrontal cortical minicolumn: from executive control to disrupted cognitive processing.Brain : a journal of neurology · 2014Review
- How to read neuron-dropping curves?Frontiers in systems neuroscience · 2014Article
- Volitional enhancement of firing synchrony and oscillation by neuronal operant conditioning: interaction with neurorehabilitation and brain-machine interface.Frontiers in systems neuroscience · 2014Review
- Nanostructures: a platform for brain repair and augmentation.Frontiers in systems neuroscience · 2014Review
- The cortical microstructural basis of lateralized cognition: a review.Frontiers in psychology · 2014Review
- Facilitation of memory encoding in primate hippocampus by a neuroprosthesis that promotes task-specific neural firing.Journal of neural engineering · 2013Article
- Nanotools for neuroscience and brain activity mapping.ACS nano · 2013Review
- Donor/recipient enhancement of memory in rat hippocampus.Frontiers in systems neuroscience · 2013Article
- Inter-laminar microcircuits across neocortex: repair and augmentation.Frontiers in systems neuroscience · 2013Article
- Prefrontal cortical microcircuits bind perception to executive control.Scientific reports · 2013Article
- The computational anatomy of psychosis.Frontiers in psychiatry · 2013Article
- Canonical circuits of the cerebral cortex as enablers of neuroprosthetics.Frontiers in systems neuroscience · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
A common denominator for many cognitive disorders of human brain is the disruption of neural activity within pFC, whose structural basis is primarily interlaminar (columnar) microcircuits or "minicolumns." The importance of this brain region for executive decision-making has been well documented; however, because of technological constraints, the minicolumnar basis is not well understood. Here, via implementation of a unique conformal multielectrode recording array, the role of interlaminar pFC minicolumns in the executive control of task-related target selection is demonstrated in nonhuman primates performing a visuomotor DMS task. The results reveal target-specific, interlaminar correlated firing during the decision phase of the trial between multielectrode recording array-isolated minicolumnar pairs of neurons located in parallel in layers 2/3 and layer 5 of pFC. The functional significance of individual pFC minicolumns (separated by 40 μm) was shown by reduced correlated firing between cell pairs within single minicolumns on error trials with inappropriate target selection. To further demonstrate dependence on performance, a task-disrupting drug (cocaine) was administered in the middle of the session, which also reduced interlaminar firing in minicolumns that fired appropriately in the early (nondrug) portion of the session. The results provide a direct demonstration of task-specific, real-time columnar processing in pFC indicating the role of this type of microcircuit in executive control of decision-making in primate brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.