ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2013
Leptin deficiency modulates allograft survival by favoring a Th2 and a regulatory immune profile. [corrected].
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of obesity with mortality and clinical outcomes in children and adolescents with transplantation: A systematic review and meta-analysis.Reviews in endocrine & metabolic disorders · 2021Pooled it
- The Intersection of the Pathogenic Processes Underlying Psoriasis and the Comorbid Condition of Obesity.Life (Basel, Switzerland) · 2024Review
- Adiponectin/leptin ratio as a predictor of acute rejection in early post-transplant period in patients after kidney transplantation.Frontiers in medicine · 2023Article
- Translating MSC Therapy in the Age of Obesity.Frontiers in immunology · 2022Review
- Early Post-Transplant Leptin Concentration Changes in Kidney Transplant Recipients.Medicina (Kaunas, Lithuania) · 2021Article
- Combined donor-recipient genotypes of leptin receptor and adiponectin gene polymorphisms affect the incidence of complications after renal transplantation.Molecular genetics and metabolism reports · 2020Article
- Association of polymorphisms in leptin and adiponectin genes with long-term outcomes in renal transplant recipients.The pharmacogenomics journal · 2020Article
- Insights into the Mechanisms That May Clarify Obesity as a Risk Factor for Multiple Sclerosis.Current neurology and neuroscience reports · 2018Review
- Changes in Nutritional Status Impact Immune Cell Metabolism and Function.Frontiers in immunology · 2018Review
- Differential Impact of Chronic Hyperglycemia on Humoral Versus Cellular Primary Alloimmunity.Diabetes · 2017Article
- Kidney disease and obesity: epidemiology, mechanisms and treatment.Nature reviews. Nephrology · 2017Review
- The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective.Journal of diabetes research · 2017Review
- Review
- Adipocytokines in renal transplant recipients.Clinical kidney journal · 2016Review
- High-Fat Diet-Induced Obesity Enhances Allograft Rejection.Transplantation · 2016Article
- Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance.Diabetes · 2016Article
- Obesity-related immune responses and their impact on surgical outcomes.International journal of obesity (2005) · 2015Review
- Adipokines as drug targets in diabetes and underlying disturbances.Journal of diabetes research · 2015Review
- The Macrophage Switch in Obesity Development.Frontiers in immunology · 2015Review
- RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance.Cell metabolism · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
Leptin, an adipose-secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lep(ob/ob) and wild-type mice. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Our data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.
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