ReviewObesity reviews : an official journal of the International Association for the Study of Obesity2013
Obesity and addiction: neurobiological overlaps.
Review in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 365 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
365 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Prevalence of food addiction in children and adolescents: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Experimental and observational studies on alcohol use and dietary intake: a systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Pooled it
- Obesity has limited behavioural overlap with addiction and psychiatric phenotypes.Nature human behaviour · 2020Pooled it
- Self-Monitoring of Weight Loss Over Time: Secondary Data Analysis of a Randomized Controlled Trial.JMIR mHealth and uHealth · 2026Trial
- Effect of the GLP-1 receptor agonist exenatide on pro-inflammatory and metabolic biomarkers in individuals with alcohol use disorder: Post hoc results from a randomized, double-blinded, placebo-controlled clinical trial.Alcohol, clinical & experimental research · 2025Trial
- Exenatide once weekly for alcohol use disorder investigated in a randomized, placebo-controlled clinical trial.JCI insight · 2022Trial
- Diets Varying in Carbohydrate Content Differentially Alter Brain Activity in Homeostatic and Reward Regions in Adults.The Journal of nutrition · 2021Trial
- Stress induced hyperphagia iniScience · 2026Article
- Identification of critical brain regions for young adults with obesity and their relationships with impulsivity using machine learning based on neuroanatomical features.International journal of obesity (2005) · 2026Article
- Using Best-Worst Scaling to explore the perceived addictiveness of foods by processing level: a cross-sectional study among higher education students in Belgium.Archives of public health = Archives belges de sante publique · 2026Article
- Addiction as a cardiometabolic disease: a neurocardiometabolic framework and the emerging role of GLP-1 receptor therapies.European heart journal open · 2026Review
- Towards an Integrative Framework of Self-Regulation: A Scoping Review on the Interplay Between Emotion Regulation, Executive Functions and Decision-Making in Clinical Populations.Brain sciences · 2026Review
- Emotional Eating Under Negative Affect: A Narrative Review from the Perspectives of Emotion Regulation and Reward Processes in Food Choice.Nutrients · 2026Review
- Glucagon-like peptide 1 receptor agonists in substance use disorders: A systematic review of ClinicalTrials.Gov.Addictive behaviors reports · 2026Article
- Review
- Food addiction as a transdiagnostic feature associated with binge-eating symptoms in eating disorders: prevalence and rehabilitation outcomes in an Italian inpatient population.Eating and weight disorders : EWD · 2026Article
- Ultra-Processed Food Consumption Is Associated With an Unfavorable Nutrient Profile and a Higher Likelihood of Hypertension Among Women Living in Brazilian Favelas.Journal of lipid and atherosclerosis · 2026Article
- History of Cannabis Use and Obesity Among U.S. Low-Income Veterans: Associations With Mental Health and Psychosocial Functioning.The Psychiatric quarterly · 2026Article
- Effects of a single dose of psilocybin on diet-induced weight loss in obese mice.Translational psychiatry · 2026Article
305 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
Drug addiction and obesity appear to share several properties. Both can be defined as disorders in which the saliency of a specific type of reward (food or drug) becomes exaggerated relative to, and at the expense of others rewards. Both drugs and food have powerful reinforcing effects, which are in part mediated by abrupt dopamine increases in the brain reward centres. The abrupt dopamine increases, in vulnerable individuals, can override the brain's homeostatic control mechanisms. These parallels have generated interest in understanding the shared vulnerabilities between addiction and obesity. Predictably, they also engendered a heated debate. Specifically, brain imaging studies are beginning to uncover common features between these two conditions and delineate some of the overlapping brain circuits whose dysfunctions may underlie the observed deficits. The combined results suggest that both obese and drug-addicted individuals suffer from impairments in dopaminergic pathways that regulate neuronal systems associated not only with reward sensitivity and incentive motivation, but also with conditioning, self-control, stress reactivity and interoceptive awareness. In parallel, studies are also delineating differences between them that centre on the key role that peripheral signals involved with homeostatic control exert on food intake. Here, we focus on the shared neurobiological substrates of obesity and addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.