ArticleBMC research notes2012
Inflammation, oxidative stress, glomerular filtration rate, and albuminuria in elderly men: a cross-sectional study.
Article in BMC research notes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Association of blood urea nitrogen to high-density lipoprotein ratio with all-cause and cardiovascular mortality in individuals with mildly reduced eGFR.Clinics (Sao Paulo, Brazil) · 2026Article
- Elevated Inflammation and Poor Diet Quality Associated with Lower eGFR in United States Adults: An NHANES 2015-2018 Analysis.Nutrients · 2024Article
- Oxidative Stress and Cardiovascular Risk Factors: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.Antioxidants (Basel, Switzerland) · 2023Article
- Renal biomarkers in cats: A review of the current status in chronic kidney disease.Journal of veterinary internal medicine · 2022Review
- Assessment of clinical variables as predictive markers in the development and progression of colorectal cancer.Bioengineered · 2021Article
- Uremic Toxins, Oxidative Stress, Atherosclerosis in Chronic Kidney Disease, and Kidney Transplantation.Oxidative medicine and cellular longevity · 2021Review
- Association Between Plasma Redox State/Mitochondria Function and a Flu-Like Syndrome/COVID-19 in the Elderly Admitted to a Long-Term Care Unit.Frontiers in physiology · 2021Article
- Oxidant stress and renal function among children with chronic kidney disease: a repeated measures study.Scientific reports · 2020Article
- Gender-biased kidney damage in mice following exposure to tobacco cigarette smoke: More protection in premenopausal females.Physiological reports · 2020Article
- Serum xanthophyll carotenoids are associated with estimated glomerular filtration rate in an aged cohort.Scientific reports · 2019Article
- Relation of Moderate Physical Activity to Blood Markers of Oxidative Stress and Antioxidant Defense in the Elderly.Oxidative medicine and cellular longevity · 2019Article
- The Benefit of Anti-Inflammatory and Renal-Protective Dietary Ingredients on the Biological Processes of Aging in the Kidney.Biology · 2018Review
- Urinary FJournal of veterinary internal medicine · 2017Article
- Renal function and coronary microvascular dysfunction in women with symptoms/signs of ischemia.PloS one · 2015Article
- Albuminuria is associated with elevated acute phase reactants and proinflammatory markers in HIV-infected patients receiving suppressive combination antiretroviral therapy.AIDS research and human retroviruses · 2014Article
- Serum gamma - glutamyltransferase is associated with albuminuria: a population-based study.PloS one · 2014Article
- Pathogenesis of chronic cardiorenal syndrome: is there a role for oxidative stress?International journal of molecular sciences · 2013Review
- Relationship between estimated glomerular filtration rate, albuminuria, and oxidant status in the Japanese population.BMC nephrology · 2013Article
- Association of serum carotenoid levels with urinary albumin excretion in a general Japanese population: the Yakumo study.Journal of epidemiology · 2013Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of inflammation and oxidative stress in mild renal impairment in the elderly is not well studied. Accordingly, we aimed at investigating the associations between estimated glomerular filtration rate (eGFR), albumin/creatinine ratio (ACR), and markers of different inflammatory pathways and oxidative stress in a community based cohort of elderly men.
findingsCystatin C-based GFR, ACR, and biomarkers of cytokine-mediated inflammation (interleukin-6, high-sensitivity C-reactive protein[CRP], serum amyloid A[SAA]), cyclooxygenase-mediated inflammation (urinary prostaglandin F2α [PGF2α]), and oxidative stress (urinary F2 isoprostanes) were assessed in the Uppsala Longitudinal Study of Adult Men(n = 647, mean age 77 years).
resultsIn linear regression models adjusting for age, BMI, smoking, blood pressure, LDL-cholesterol, HDL-cholesterol, triglycerides, and treatment with statins, ACE-inhibitors, ASA, and anti-inflammatory agents, eGFR was inversely associated with CRP, interleukin-6, and SAA (β-coefficient -0.13 to -0.19, p < 0.001 for all), and positively associated with urinary F2-isoprostanes (β-coefficient 0.09, p = 0.02). In line with this, ACR was positively associated with CRP, interleukin-6, and SAA (β- coefficient 0.09-0.12, p < 0.02 for all), and negatively associated with urinary F2-isoprostanes (β-coefficient -0.12, p = 0.002). The associations were similar but with lower regression coefficients in a sub-sample with normal eGFR (>60 ml/min/1.73 m2, n = 514), with the exception that F2-isoprostane and SAA were no longer associated with eGFR.
conclusionOur data indicate that cytokine-mediated inflammation is involved in the early stages of impaired kidney function in the elderly, but that cyclooxygenase-mediated inflammation does not play a role at this stage. The unexpected association between higher eGFR/lower albuminuria and increased F2-isoprostanes in urine merits further studies.
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