ArticleBeilstein journal of nanotechnology2012
Magnetic-Fe/Fe(3)O(4)-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages.
Article in Beilstein journal of nanotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 66 citations in OpenAlex.
- Magnetic-Plasmonic Core-Shell Nanoparticles: Properties, Synthesis and Applications for Cancer Detection and Treatment.Nanomaterials (Basel, Switzerland) · 2025Review
- Treating Primary Aldosteronism-Induced Hypertension: Novel Approaches and Future Outlooks.Endocrine reviews · 2024Article
- Research Progress of SN38 Drug Delivery System in Cancer Treatment.International journal of nanomedicine · 2024Review
- Tumor-associated macrophages in nanomaterial-based anti-tumor therapy: as target spots or delivery platforms.Frontiers in bioengineering and biotechnology · 2023Review
- A narrative review of tumor-associated macrophages in lung cancer: regulation of macrophage polarization and therapeutic implications.Translational lung cancer research · 2021Review
- Magnetic and near-infrared derived heating characteristics of dimercaptosuccinic acid coated uniform Fe@FeNano convergence · 2020Article
- Stimuli-responsive prodrug-based cancer nanomedicine.EBioMedicine · 2020Review
- Peptide nanosponges designed for rapid uptake by leukocytes and neural stem cells.RSC advances · 2018Article
- Tumor-Associated Macrophages as Target for Antitumor Therapy.Archivum immunologiae et therapiae experimentalis · 2018Review
- High-Temperature Stress Alleviation by Selenium Nanoparticle Treatment in Grain Sorghum.ACS omega · 2018Article
- Synergy of Iron Chelators and Therapeutic Peptide Sequences Delivered via a Magnetic Nanocarrier.Journal of functional biomaterials · 2017Article
- Experimental Investigation of Magnetic Nanoparticle-Enhanced Microwave Hyperthermia.Journal of functional biomaterials · 2017Article
- Tumor-associated macrophages, potential targets for cancer treatment.Biomarker research · 2017Review
- Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection.Beilstein journal of nanotechnology · 2016Article
- Utilization of Enzyme-Immobilized Mesoporous Silica Nanocontainers (IBN-4) in Prodrug-Activated Cancer Theranostics.Nanomaterials (Basel, Switzerland) · 2015Article
- Targeted drug delivery using genetically engineered diatom biosilica.Nature communications · 2015Article
- Synthesis, characterization and in vitro biocompatibility study of Au/TMC/Fe3O4 nanocomposites as a promising, nontoxic system for biomedical applications.Beilstein journal of nanotechnology · 2015Article
- Macrophages associated with tumors as potential targets and therapeutic intermediates.Nanomedicine (London, England) · 2014Review
- Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer.Beilstein journal of nanotechnology · 2014Article
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The targeted delivery of therapeutics to the tumor site is highly desirable in cancer treatment, because it is capable of minimizing collateral damage. Herein, we report the synthesis of a nanoplatform, which is composed of a 15 ± 1 nm diameter core/shell Fe/Fe(3)O(4) magnetic nanoparticles (MNPs) and the topoisomerase I blocker SN38 bound to the surface of the MNPs via a carboxylesterase cleavable linker. This nanoplatform demonstrated high heating ability (SAR = 522 ± 40 W/g) in an AC-magnetic field. For the purpose of targeted delivery, this nanoplatform was loaded into tumor-homing double-stable RAW264.7 cells (mouse monocyte/macrophage-like cells (Mo/Ma)), which have been engineered to express intracellular carboxylesterase (InCE) upon addition of doxycycline by a Tet-On Advanced system. The nanoplatform was taken up efficiently by these tumor-homing cells. They showed low toxicity even at high nanoplatform concentration. SN38 was released successfully by switching on the Tet-On Advanced system. We have demonstrated that this nanoplatform can be potentially used for thermochemotherapy. We will be able to achieve the following goals: (1) Specifically deliver the SN38 prodrug and magnetic nanoparticles to the cancer site as the payload of tumor-homing double-stable RAW264.7 cells; (2) Release of chemotherapeutic SN38 at the cancer site by means of the self-containing Tet-On Advanced system; (3) Provide localized magnetic hyperthermia to enhance the cancer treatment, both by killing cancer cells through magnetic heating and by activating the immune system.
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