SynthesisNutrients2012
The relationship between zinc intake and serum/plasma zinc concentration in children: a systematic review and dose-response meta-analysis.
Synthesis in Nutrients, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies.Scientific reports · 2021Pooled it
- Pooled it
- Zinc intake, status and indices of cognitive function in adults and children: a systematic review and meta-analysis.European journal of clinical nutrition · 2015Pooled it
- The relationship between zinc intake and growth in children aged 1-8 years: a systematic review and meta-analysis.European journal of clinical nutrition · 2015Pooled it
- Effect of zinc intake on serum/plasma zinc status in infants: a meta-analysis.Maternal & child nutrition · 2013Pooled it
- The Impact of a Low-Carbohydrate Diet on Micronutrient Intake and Status in Adolescents with Type 1 Diabetes.Nutrients · 2023Trial
- The effect of zinc-biofortified rice on zinc status of Bangladeshi preschool children: a randomized, double-masked, household-based, controlled trial.The American journal of clinical nutrition · 2022Trial
- Childhood stunting and micronutrient status unaffected by RCT of micronutrient fortified drink.Maternal & child nutrition · 2022Trial
- Prevalence of Zinc Deficiency in Healthy 1-3-Year-Old Children from Three Western European Countries.Nutrients · 2021Trial
- Trial
- Effect of African leafy vegetables on the micronutrient status of mildly deficient farm-school children in South Africa: a randomized controlled study.Public health nutrition · 2016Trial
- Zinc Homeostasis and the Risk of Type 2 Diabetes: Complex Role of ZnT8 in Insulin and Glucagon Secretion.Current nutrition reports · 2026Review
- Type 2 diabetes mellitus and zinc dysregulation: From basic and epidemiological evidence to interventions.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2025Review
- Micronutrient Biomarker Selection and Assay Methods and Performance in Double-Blind, Randomized, Controlled Micronutrient Dose Response (MiNDR) Trials among Women of Reproductive Age and Pregnant Women in Rural Bangladesh.Current developments in nutrition · 2025Article
- Zinc-Biofortified Rice Improves Growth in Zinc-Deficient Rats.Biological trace element research · 2025Article
- Selenium, zinc, and copper intake and status of vegetarian, vegan, and omnivore children and adolescents: results of the VeChi youth study.European journal of nutrition · 2025Article
- Association of Magnesium, Iron, Copper, and Zinc Levels with the Prevalence of Behavior Problems in Children and Adolescents.Biological trace element research · 2024Article
- Determination of the median lethal dose of zinc gluconate in mice and safety evaluation.BMC pharmacology & toxicology · 2024Article
- Exploring zinc deficiency using serum Zn levels: consequences and potential solutions in suckling pigs.Journal of animal science · 2024Article
- The Efficacy of Zinc Gluconate Supplementation in the Improvement of Malnutrition Indices and Skin Abnormalities in Hemodialysis Patients: A Randomized Clinical Trial.International journal of preventive medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recommendations for zinc intake during childhood vary widely across Europe. The EURRECA project attempts to consolidate the basis for the definition of micronutrient requirements, taking into account relationships among intake, status and health outcomes, in order to harmonise these recommendations. Data on zinc intake and biomarkers of zinc status reported in randomised controlled trials (RCTs) can provide estimates of dose-response relationships which may be used for underpinning zinc reference values. This systematic review included all RCTs of apparently healthy children aged 1-17 years published by February 2010 which provided data on zinc intake and biomarkers of zinc status. An intake-status regression coefficient (β) was calculated for each individual study and calculated the overall pooled and SE (β) using random effects meta-analysis on a double log scale. The pooled dose-response relationship between zinc intake and zinc status indicated that a doubling of the zinc intake increased the serum/plasma zinc status by 9%. This evidence can be utilised, together with currently used balance studies and repletion/depletion studies, when setting zinc recommendations as a basis for nutrition policies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.