ArticleSports health2012
A theoretical framework for understanding neuromuscular response to lower extremity joint injury.
Article in Sports health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04261049 (Effect of ZILRETTA Injection on Neuromuscular Function, Gait Biomechanics and Physical Performance), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of ZILRETTA Injection on Neuromuscular Function, Gait Biomechanics and Physical Performance
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Brain Neuroplasticity Related to Lateral Ankle Ligamentous Injuries: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- A Comparison of Neuromuscular Electrical Stimulation Parameters for Postoperative Quadriceps Strength in Patients After Knee Surgery: A Systematic Review.Sports health · 2021Pooled it
- Therapeutic Interventions for Scapular Kinematics and Disability in Patients With Subacromial Impingement: A Systematic Review.Journal of athletic training · 2019Pooled it
- The Impact of a Single Hip Manipulation on Quadriceps Activity and Performance: A Randomized Study.Biomedicines · 2025Article
- Clinical Features Post-Anterior Cruciate Ligament Reconstruction Associated With Structural Alterations in the Corticospinal Tract.Journal of athletic training · 2025Article
- Relating cortical morphology, corticospinal excitability, corticomotor representation, and quadriceps strength after anterior cruciate ligament injury.Experimental brain research · 2025Article
- Muscle-specific ERRγ activation mitigates muscle atrophy after ACL injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Neurophysiology of ACL Injury.Orthopedic reviews · 2025Article
- Rebuilding Stability: Exploring the Best Rehabilitation Methods for Chronic Ankle Instability.Sports (Basel, Switzerland) · 2024Review
- Sensorimotor Dysfunction Following Anterior Cruciate Ligament Reconstruction- an Afferent Perspective: A Scoping Review.International journal of sports physical therapy · 2024Article
- Patients with chronic ankle instability exhibit increased sensorimotor cortex activation and correlation with poorer lateral balance control ability during single-leg stance: a FNIRS study.Frontiers in human neuroscience · 2024Article
- Effects of dual-task paradigm on the injury potential during landing among individuals with chronic ankle instability.Frontiers in physiology · 2024Article
- Long-Lasting Impairments in Quadriceps Mitochondrial Health, Muscle Size, and Phenotypic Composition Are Present After Non-invasive Anterior Cruciate Ligament Injury.Frontiers in physiology · 2022Article
- Protracted alterations in muscle activation strategies and knee mechanics in patients after Anterior Cruciate Ligament Reconstruction.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Article
- Quadriceps Inhibition After Naturally Occurring Patellar Tendon Damage and Pain.Journal of athletic training · 2020Article
- Reduced strength, poor balance and concern about falls mediate the relationship between knee pain and fall risk in older people.BMC geriatrics · 2020Article
- Quadriceps muscle function following anterior cruciate ligament reconstruction: systemic differences in neural and morphological characteristics.Experimental brain research · 2019Article
- Deficits in Quadriceps Force Control After Anterior Cruciate Ligament Injury: Potential Central Mechanisms.Journal of athletic training · 2019Article
- Learned Helplessness After Anterior Cruciate Ligament Reconstruction: An Altered Neurocognitive State?Sports medicine (Auckland, N.Z.) · 2019Article
- Quadriceps Neuromuscular Function and Jump-Landing Sagittal-Plane Knee Biomechanics After Anterior Cruciate Ligament Reconstruction.Journal of athletic training · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuromuscular alterations are common following lower extremity joint injury and often lead to decreased function and disability. These neuromuscular alterations manifest in inhibition or abnormal facilitation of the uninjured musculature surrounding an injured joint. Unfortunately, these neural alterations are poorly understood, which may affect clinical recognition and treatment of these injuries. Understanding how these neural alterations affect physical function may be important for proper clinical management of lower extremity joint injuries.
methodsPertinent articles focusing on neuromuscular consequences and treatment of knee and ankle injuries were collected from peer-reviewed sources available on the Web of Science and Medline databases from 1975 through 2010. A theoretical model to illustrate potential relationships between neural alterations and clinical impairments was constructed from the current literature.
resultsLower extremity joint injury affects upstream cortical and spinal reflexive excitability pathways as well as downstream muscle function and overall physical performance. Treatment targeting the central nervous system provides an alternate means of treating joint injury that may be effective for patients with neuromuscular alterations.
conclusionsDisability is common following joint injury. There is mounting evidence that alterations in the central nervous system may relate to clinical changes in biomechanics that may predispose patients to further injury, and novel clinical interventions that target neural alterations may improve therapeutic outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.