Evidence map›Paper›PMID 23015990›Full record

ArticleSports health2011

Pathophysiology of sports-related concussion: an update on basic science and translational research.

Christopher C Giza, John P Difiori

Abstract read
In one paragraph

Article in Sports health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Safety and Prognostic Utility of Provocative Exercise Testing in Acutely Concussed Adolescents: A Randomized Trial.Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine · 2018
    Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Exercise is Medicine for Concussion.Current sports medicine reports · 2018
    Review
  9. Review
  10. Blood biomarkers for brain injury: What are we measuring?Neuroscience and biobehavioral reviews · 2016
    Review
  11. Article
  12. Social norms theory and concussion education.Health education research · 2015
    Article
  13. Sports-Related Concussion.Current pain and headache reports · 2015
    Review
  14. Review
  15. Article
  16. Sports concussion diagnosis and management.Continuum (Minneapolis, Minn.) · 2014
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christopher C GizaBrain Injury Research Center, University of California, Los Angeles, California.
John P Difiori

Funding

Using glutamatergic pharmacotherapy to optimize TBI recoveryR01NS027544 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOVDA, DAVID A · 1990 to 2017
$3.8M
Restoration of plasticity after pediatric traumatic brain injuryK02NS057420 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GIZA, CHRISTOPHER C · 2007 to 2009
$533k
NINDS NIH HHS K02 NS057420NINDS NIH HHS R01 NS027544
6 · The paper itself

Abstract

contextConcussions that occur during participation in athletic events affect millions of individuals each year. Although our understanding of the pathophysiology of concussion has grown considerably in recent years, much remains to be elucidated. This article reviews basic science and relevant translational clinical research regarding several aspects of concussion. EVIDENCE ACQUISITION: A literature search was conducted using PubMed from 1966 to 2010, with an emphasis on work published within the past 10 years. Additional articles were identified from the bibliography of recent reviews.

resultsBasic science and clinical data both indicate that there is a period of increased vulnerability to repeated injury following a concussion and that its duration is variable. Growing evidence indicates that postinjury activity is likely to affect recovery from brain injury. Data suggest that long-term sequelae may result from prior concussion-particularly, repeated injuries. The unique aspects of cerebral development may account for differences in the effects of concussion in children and adolescents when compared with adults.

conclusionsThe available pathophysiologic data from basic science and clinical studies have increased the evidence base for concussion management strategies-the approaches to which may differ between young athletes and adults.

Indexed as

concussionpathologysports

Identifiers

PMID23015990
PMCPMC3445184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.