ArticleFrontiers in human neuroscience2012
The extended fronto-striatal model of obsessive compulsive disorder: convergence from event-related potentials, neuropsychology and neuroimaging.
Article in Frontiers in human neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 106 citations in OpenAlex.
- Reaction Time Variability and Electrophysiological Indices of Performance Monitoring in Youths With Attention-Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder.Psychophysiology · 2026Article
- The potential of event-related beta oscillations as biomarkers for neuromodulatory treatment efficacy.Frontiers in psychology · 2026Article
- Exploring potential resting-state EEG biomarkers of obsessive-compulsive disorder based on explainable machine learning analysis of independent training and test samples.BMC psychiatry · 2025Article
- Working memory load-dependent modulation of neural activity predicts response to cognitive behavioral therapy in obsessive-compulsive disorder.Translational psychiatry · 2025Article
- Deep brain stimulation for refractory obsessive-compulsive disorder: A review and analysis of the FDA MAUDE database.Surgical neurology international · 2022Article
- Polygenic risk for obsessive-compulsive disorder (OCD) predicts brain response during working memory task in OCD, unaffected relatives, and healthy controls.Scientific reports · 2021Observational
- Brain Activation of Patients With Obsessive-Compulsive Disorder During a Mental Rotation Task: A Functional MRI Study.Frontiers in psychiatry · 2021Article
- Social Cognition and Obsessive-Compulsive Disorder: A Review of Subdomains of Social Functioning.Frontiers in psychiatry · 2020Review
- Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2019Article
- Neurocognitive function in paediatric obsessive-compulsive disorder.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2018Article
- Neural correlates of working memory deficits and associations to response inhibition in obsessive compulsive disorder.NeuroImage. Clinical · 2018Article
- The Neural Correlates of Probabilistic Classification Learning in Obsessive-Compulsive Disorder: A Pilot Study.Frontiers in psychiatry · 2018Article
- Increased Attentional Bias Toward Visual Cues in Internet Gaming Disorder and Obsessive-Compulsive Disorder: An Event-Related Potential Study.Frontiers in psychiatry · 2018Article
- Differential pattern of brain functional connectome in obsessive-compulsive disorder versus healthy controls.EXCLI journal · 2018Article
- The neural correlates of obsessive-compulsive disorder: a multimodal perspective.Translational psychiatry · 2017Article
- Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2017Review
- Neurophysiological correlates of altered response inhibition in internet gaming disorder and obsessive-compulsive disorder: Perspectives from impulsivity and compulsivity.Scientific reports · 2017Article
- Commentary: Deficient approaches to human neuroimaging.Frontiers in human neuroscience · 2017Article
- The crossroads of anxiety: distinct neurophysiological maps for different symptomatic groups.Neuropsychiatric disease and treatment · 2016Article
- Linking Resting-State Networks in the Prefrontal Cortex to Executive Function: A Functional Near Infrared Spectroscopy Study.Frontiers in neuroscience · 2016Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
In this work, we explored convergent evidence supporting the fronto-striatal model of obsessive-compulsive disorder (FSMOCD) and the contribution of event-related potential (ERP) studies to this model. First, we considered minor modifications to the FSMOCD model based on neuroimaging and neuropsychological data. We noted the brain areas most affected in this disorder -anterior cingulate cortex (ACC), basal ganglia (BG), and orbito-frontal cortex (OFC) and their related cognitive functions, such as monitoring and inhibition. Then, we assessed the ERPs that are directly related to the FSMOCD, including the error-related negativity (ERN), N200, and P600. Several OCD studies present enhanced ERN and N2 responses during conflict tasks as well as an enhanced P600 during working memory (WM) tasks. Evidence from ERP studies (especially regarding ERN and N200 amplitude enhancement), neuroimaging and neuropsychological findings suggests abnormal activity in the OFC, ACC, and BG in OCD patients. Moreover, additional findings from these analyses suggest dorsolateral prefrontal and parietal cortex involvement, which might be related to executive function (EF) deficits. Thus, these convergent results suggest the existence of a self-monitoring imbalance involving inhibitory deficits and executive dysfunctions. OCD patients present an impaired ability to monitor, control, and inhibit intrusive thoughts, urges, feelings, and behaviors. In the current model, this imbalance is triggered by an excitatory role of the BG (associated with cognitive or motor actions without volitional control) and inhibitory activity of the OFC as well as excessive monitoring of the ACC to block excitatory impulses. This imbalance would interact with the reduced activation of the parietal-DLPC network, leading to executive dysfunction. ERP research may provide further insight regarding the temporal dynamics of action monitoring and executive functioning in OCD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.