ArticleFrontiers in neural circuits2012
Multiple embryonic origins of nitric oxide synthase-expressing GABAergic neurons of the neocortex.
Article in Frontiers in neural circuits, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Developing mouse inhibitory neuron single-cell transcriptomes reveal distinct modes of cell-type diversification.Nature neuroscience · 2026Article
- A single-cell transcriptomic atlas of developing inhibitory neurons reveals expanding and contracting modes of diversification.bioRxiv : the preprint server for biology · 2025Article
- Cortical somatostatin long-range projection neurons and interneurons exhibit divergent developmental trajectories.Neuron · 2024Article
- Development, Diversity, and Death of MGE-Derived Cortical Interneurons.International journal of molecular sciences · 2021Review
- Transient developmental imbalance of cortical interneuron subtypes presages long-term changes in behavior.Cell reports · 2021Article
- Opioid Modulation of Neuronal Iron and Potential Contributions to NeuroHIV.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Neurovascular Coupling under Chronic Stress Is Modified by Altered GABAergic Interneuron Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Hippocampal CA1 Somatostatin Interneurons Originate in the Embryonic MGE/POA.Stem cell reports · 2019Article
- Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics.PLoS biology · 2018Article
- Stranger in a Strange Land: Using Heterotopic Transplantations to Study Nature vs Nurture in Brain Development.Journal of experimental neuroscience · 2018Article
- Heterotopic Transplantations Reveal Environmental Influences on Interneuron Diversity and Maturation.Cell reports · 2017Article
- NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory.Cell reports · 2017Article
- Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex.Neuron · 2016Article
- Ontogenesis of NADPH-diaphorase positive neurons in guinea pig neocortex.Frontiers in neuroanatomy · 2015Article
- Characterization and distribution of Reelin-positive interneuron subtypes in the rat barrel cortex.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Revisiting enigmatic cortical calretinin-expressing interneurons.Frontiers in neuroanatomy · 2014Review
- Beyond the frontiers of neuronal types.Frontiers in neural circuits · 2013Article
- PROX1: a lineage tracer for cortical interneurons originating in the lateral/caudal ganglionic eminence and preoptic area.PloS one · 2013Article
- Cortical NO interneurons: from embryogenesis to functions.Frontiers in neural circuits · 2013Review
- Neuronal nitric oxide synthase expressing neurons: a journey from birth to neuronal circuits.Frontiers in neural circuits · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
cortical gabaergic interneurons in rodents originate in three subcortical regionsthe medial ganglionic eminence (MGE), the lateral/caudal ganglionic eminence (LGE/CGE), and the preoptic area (POA). Each of these neuroepithelial precursor domains contributes different interneuron subtypes to the cortex. Neuronal NOS (nNOS)-expressing neurons represent a heterogenous population of cortical interneurons. We examined the development of these cells in the mouse embryonic cortex and their abundance and distribution in adult animals. Using genetic lineage tracing in transgenic mice we find that nNOS type I cells originate only in the MGE whereas type II cells have a triple origin in the MGE, LGE/CGE, and POA. The two populations are born at different times during development, occupy different layers in the adult cortex and have distinct neurochemical profiles. nNOS neurons are more numerous in the adult cortex than previously reported and constitute a significant proportion of the cortical interneuron population. Our data suggest that the heterogeneity of nNOS neurons in the cortex can be attributed to their multiple embryonic origins which likely impose distinct genetic specification programs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.