ArticleMarine drugs2012
Gene sequence based clustering assists in dereplication of Pseudoalteromonas luteoviolacea strains with identical inhibitory activity and antibiotic production.
Article in Marine drugs, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Genome- and metabolome-guided discovery of marine BamA inhibitors revealed a dedicated darobactin halogenase.Cell chemical biology · 2023Article
- Exploring the Antibiotic Production Potential of Heterotrophic Bacterial Communities Isolated from the Marine SpongesMarine drugs · 2022Article
- Genetic examination of the marine bacterium Pseudoalteromonas luteoviolacea and effects of its metamorphosis-inducing factors.Environmental microbiology · 2020Article
- Diversity and distribution of the bmp gene cluster and its Polybrominated products in the genus Pseudoalteromonas.Environmental microbiology · 2019Article
- Antibacterial Activities of Bacteria Isolated from the Marine Sponges Isodictya compressa and Higginsia bidentifera Collected from Algoa Bay, South Africa.Marine drugs · 2017Article
- Production of the Bioactive Compounds Violacein and Indolmycin Is Conditional in aFrontiers in microbiology · 2016Article
- Genome mining reveals unlocked bioactive potential of marine Gram-negative bacteria.BMC genomics · 2015Article
- Violacein: Properties and Production of a Versatile Bacterial Pigment.BioMed research international · 2015Review
- The antimicrobial activity of heterotrophic bacteria isolated from the marine sponge Erylus deficiens (Astrophorida, Geodiidae).Frontiers in microbiology · 2015Article
- The chemical cue tetrabromopyrrole from a biofilm bacterium induces settlement of multiple Caribbean corals.Proceedings. Biological sciences · 2014Article
- Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some microbial species are chemically homogenous, and the same secondary metabolites are found in all strains. In contrast, we previously found that five strains of P. luteoviolacea were closely related by 16S rRNA gene sequence but produced two different antibiotic profiles. The purpose of the present study was to determine whether such bioactivity differences could be linked to genotypes allowing methods from phylogenetic analysis to aid in selection of strains for biodiscovery. Thirteen P. luteoviolacea strains divided into three chemotypes based on production of known antibiotics and four antibacterial profiles based on inhibition assays against Vibrio anguillarum and Staphylococcus aureus. To determine whether chemotype and inhibition profile are reflected by phylogenetic clustering we sequenced 16S rRNA, gyrB and recA genes. Clustering based on 16S rRNA gene sequences alone showed little correlation to chemotypes and inhibition profiles, while clustering based on concatenated 16S rRNA, gyrB, and recA gene sequences resulted in three clusters, two of which uniformly consisted of strains of identical chemotype and inhibition profile. A major time sink in natural products discovery is the effort spent rediscovering known compounds, and this study indicates that phylogeny clustering of bioactive species has the potential to be a useful dereplication tool in biodiscovery efforts.
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