ArticleSchizophrenia bulletin2013
Structural brain alterations associated with schizophrenia preceded by conduct disorder: a common and distinct subtype of schizophrenia?
Article in Schizophrenia bulletin, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Variation in fourteen brain structure volumes in schizophrenia: A comprehensive meta-analysis of 246 studies.Neuroscience and biobehavioral reviews · 2019Pooled it
- [Schizophrenia and violence].Der Nervenarzt · 2014Pooled it
- Individual-level deviations from normative brain morphology in violence, psychosis, and psychopathy.Translational psychiatry · 2025Article
- Altered Neural Activation in First Episode Psychosis Patients With Comorbid Conduct Disorder: A Pilot Investigation.JAACAP open · 2025Article
- Hypothalamic Subunit Volumes in Schizophrenia and Bipolar Spectrum Disorders.Schizophrenia bulletin · 2024Article
- Brain structural alterations associated with impulsiveness in male violent patients with schizophrenia.BMC psychiatry · 2024Article
- Neuroanatomical correlates of aggressiveness: a case-control voxel- and surface-based morphometric study.Brain structure & function · 2024Article
- DSM-5 conduct disorder and symptoms in youths at high risk of psychosis in Kenya with DSM-5 mental disorders and substance use: towards integrated management.Scientific reports · 2023Article
- Hypothalamic volume in pedophilia with or without child sexual offense.European archives of psychiatry and clinical neuroscience · 2023Article
- Structural Deficits in the Frontotemporal Network Associated With Psychopathic Traits in Violent Offenders With Schizophrenia.Frontiers in psychiatry · 2022Article
- Female Forensic Patients May Be an Atypical Sub-type of Females Presenting Aggressive and Antisocial Behavior.Frontiers in psychiatry · 2022Review
- Could Expanding and Investing in First-Episode Psychosis Services Prevent Aggressive Behaviour and Violent Crime?Frontiers in psychiatry · 2022Review
- Identifying subtypes of bipolar disorder based on clinical and neurobiological characteristics.Scientific reports · 2021Article
- The Deficits of Individual Morphological Covariance Network Architecture in Schizophrenia Patients With and Without Violence.Frontiers in psychiatry · 2021Article
- Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence.European archives of psychiatry and clinical neuroscience · 2020Article
- Volumetric Abnormalities in Violent Schizophrenia Patients on the General Psychiatric Ward.Frontiers in psychiatry · 2020Article
- Violent Behavior Is Associated With Emotion Salience Network Dysconnectivity in Schizophrenia.Frontiers in psychiatry · 2020Article
- The neural basis of hostility-related dimensions in schizophrenia.Epidemiology and psychiatric sciences · 2018Review
- Understanding the Demographic Predictors and Associated Comorbidities in Children Hospitalized with Conduct Disorder.Behavioral sciences (Basel, Switzerland) · 2018Article
- Structural Magnetic Resonance Imaging Correlates of Aggression in Psychosis: A Systematic Review and Effect Size Analysis.Frontiers in psychiatry · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conduct disorder (CD) prior to age 15 is a precursor of schizophrenia in a minority of cases and is associated with violent behavior through adulthood, after taking account of substance misuse. The present study used structural magnetic imaging to examine gray matter (GM) volumes among 27 men with schizophrenia preceded by CD (SZ+CD), 23 men with schizophrenia but without CD (SZ-CD), 27 men with CD only (CD), and 25 healthy (H) men. The groups with schizophrenia were similar in terms of age of onset and duration of illness, levels of psychotic symptoms, and medication. The 2 groups with CD were similar as to number of CD symptoms, lifelong aggressive behavior, and number of criminal convictions. Men with SZ+CD, relative to those with SZ-CD, displayed (1) increased GM volumes in the hypothalamus, the left putamen, the right cuneus/precuneus, and the right inferior parietal cortex after controlling for age, alcohol, and drug misuse and (2) decreased GM volumes in the inferior frontal region. Men with SZ+CD (relative to the SZ-CD group) and CD (relative to the H group) displayed increased GM volumes of the hypothalamus and the inferior and superior parietal lobes, which were not associated with substance misuse. Aggressive behavior, both prior to age 15 and lifetime tendency, was positively correlated with the GM volume of the hypothalamus. Thus, among males, SZ+CD represents a distinct subtype of schizophrenia. Although differences in behavior emerge in childhood and remain stable through adulthood, further research is needed to determine whether the differences in GM volumes result from abnormal neural development distinct from that of other males developing schizophrenia.
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