ArticleProceedings. Biological sciences2012
Virulence, drug sensitivity and transmission success in the rodent malaria, Plasmodium chabaudi.
Article in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence.The Journal of infectious diseases · 2013Trial
- Virulence is associated with daily rhythms in the within-host replication of the malaria parasiteEvolutionary applications · 2024Article
- Variation among strains of Borrelia burgdorferi in host tissue abundance and lifetime transmission determine the population strain structure in nature.PLoS pathogens · 2023Article
- Which 'imperfect vaccines' encourage the evolution of higher virulence?Evolution, medicine, and public health · 2022Article
- Treating symptomatic infections and the co-evolution of virulence and drug resistance.Peer community journal · 2021Article
- Daily rhythms of both host and parasite affect antimalarial drug efficacy.Evolution, medicine, and public health · 2021Article
- Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development.Scientific reports · 2020Article
- Altered life history strategies protect malaria parasites against drugs.Evolutionary applications · 2018Article
- Reversing resistance: different routes and common themes across pathogens.Proceedings. Biological sciences · 2017Review
- Phenotypic plasticity in reproductive effort: malaria parasites respond to resource availability.Proceedings. Biological sciences · 2017Article
- Modelling the evolution of HIV-1 virulence in response to imperfect therapy and prophylaxis.Evolutionary applications · 2017Article
- Antibody-independent mechanisms regulate the establishment of chronic Plasmodium infection.Nature microbiology · 2017Article
- Kin Discrimination in Protists: From Many Cells to Single Cells and Backwards.The Journal of eukaryotic microbiology · 2016Article
- Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model.Scientific reports · 2016Article
- Potential drivers of virulence evolution in aquaculture.Evolutionary applications · 2016Article
- Understanding genetic variation in in vivo tolerance to artesunate: implications for treatment efficacy and resistance monitoring.Evolutionary applications · 2015Article
- Within-host competition does not select for virulence in malaria parasites; studies with Plasmodium yoelii.PLoS pathogens · 2015Article
- Disrupting rhythms in Plasmodium chabaudi: costs accrue quickly and independently of how infections are initiated.Malaria journal · 2013Article
- The interplay between drug resistance and fitness in malaria parasites.Molecular microbiology · 2013Review
- Variation in host resistance could limit the spread of more broadly virulent pathogens.Virulence · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Here, we test the hypothesis that virulent malaria parasites are less susceptible to drug treatment than less virulent parasites. If true, drug treatment might promote the evolution of more virulent parasites (defined here as those doing more harm to hosts). Drug-resistance mechanisms that protect parasites through interactions with drug molecules at the sub-cellular level are well known. However, parasite phenotypes associated with virulence might also help parasites survive in the presence of drugs. For example, rapidly replicating parasites might be better able to recover in the host if drug treatment fails to eliminate parasites. We quantified the effects of drug treatment on the in-host survival and between-host transmission of rodent malaria (Plasmodium chabaudi) parasites which differed in virulence and had never been previously exposed to drugs. In all our treatment regimens and in single- and mixed-genotype infections, virulent parasites were less sensitive to pyrimethamine and artemisinin, the two antimalarial drugs we tested. Virulent parasites also achieved disproportionately greater transmission when exposed to pyrimethamine. Overall, our data suggest that drug treatment can select for more virulent parasites. Drugs targeting transmission stages (such as artemisinin) may minimize the evolutionary advantage of virulence in drug-treated infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.