ArticleJournal of cell science2013
Clathrin is not required for SNX-BAR-retromer-mediated carrier formation.
Article in Journal of cell science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Recycling of Vps68 depends on retromer and Mvp1/SNX8.Biology open · 2026Article
- Assembly and fission of tubular carriers mediating protein sorting in endosomes.Nature reviews. Molecular cell biology · 2024Review
- CHC22 clathrin recruitment to the early secretory pathway requires two-site interaction with SNX5 and p115.The EMBO journal · 2024Article
- Dysregulation of SNX1-retromer axis in pharmacogenetic models of Parkinson's disease.Cell death discovery · 2024Article
- Architecture of the ESCPE-1 membrane coat.Nature structural & molecular biology · 2023Article
- Receptor Recycling by Retromer.Molecular and cellular biology · 2023Review
- Protein sorting from endosomes to the TGN.Frontiers in cell and developmental biology · 2023Review
- Proteomic characterization of isolated Arabidopsis clathrin-coated vesicles reveals evolutionarily conserved and plant-specific components.The Plant cell · 2022Article
- Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases.Frontiers in aging neuroscience · 2022Review
- Endosomal microdomains: Formation and function.Current opinion in cell biology · 2020Review
- Retrograde Transport by Clathrin-Coated Vesicles is Involved in Intracellular Transport of PrPScientific reports · 2018Article
- Article
- Lmo1656 is a secreted virulence factor ofThe Journal of biological chemistry · 2018Article
- Sorting nexin 3 mutation impairs development and neuronal function in Caenorhabditis elegans.Cellular and molecular life sciences : CMLS · 2018Article
- SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Receptor-mediated Endocytosis 8 Utilizes an N-terminal Phosphoinositide-binding Motif to Regulate Endosomal Clathrin Dynamics.The Journal of biological chemistry · 2015Article
- Review
- Unconventional functions for clathrin, ESCRTs, and other endocytic regulators in the cytoskeleton, cell cycle, nucleus, and beyond: links to human disease.Cold Spring Harbor perspectives in biology · 2014Review
- Rapid mapping of interactions between Human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy.Molecular & cellular proteomics : MCP · 2014Article
- Dynamics and instabilities of lipid bilayer membrane shapes.Advances in colloid and interface science · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Clathrin has been implicated in retromer-mediated trafficking, but its precise function remains elusive. Given the importance of retromers for efficient endosomal sorting, we have sought to clarify the relationship between clathrin and the SNX-BAR retromer. We find that the retromer SNX-BARs do not interact directly or indirectly with clathrin. In addition, we observe that SNX-BAR-retromer tubules and carriers are not clathrin coated. Furthermore, perturbing clathrin function, by overexpressing a dominant-negative clathrin or through suppression of clathrin expression, has no detectable effect on the frequency of SNX-BAR-retromer tubulation. We propose that SNX-BAR-retromer-mediated membrane deformation and carrier formation does not require clathrin, and hence the role of clathrin in SNX-BAR-retromer function would appear to lie in pre-SNX-BAR-retromer cargo sorting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.