ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Striatal indirect pathway contributes to selection accuracy of learned motor actions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The functional neural architecture of dysfunctional reward processing in autism.NeuroImage. Clinical · 2021Pooled it
- Targeting of specific neuronal types in the non-human primate brain by using a murine CD25-specific recombinant immunotoxin.Scientific reports · 2026Article
- Selective Neural Pathway Targeting by Using Lentiviral Vectors.Methods in molecular biology (Clifton, N.J.) · 2026Article
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- Enhancing reinforcement learning models by including direct and indirect pathways improves performance on striatal dependent tasks.PLoS computational biology · 2023Article
- Aberrant prefrontal cortical-striatal functional connectivity in children with primary complex motor stereotypies.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
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- Male-specific deficits in natural reward learning in a mouse model of neurodevelopmental disorders.Molecular psychiatry · 2018Article
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- Dopamine D2L Receptor Is Required for Visual Discrimination and Reversal Learning.Molecular neuropsychiatry · 2016Article
- Neurophysiology of Reward-Guided Behavior: Correlates Related to Predictions, Value, Motivation, Errors, Attention, and Action.Current topics in behavioral neurosciences · 2016Review
- From ventral-medial to dorsal-lateral striatum: neural correlates of reward-guided decision-making.Neurobiology of learning and memory · 2015Review
- Differential organization of cortical inputs to striatal projection neurons of the matrix compartment in rats.Frontiers in systems neuroscience · 2015Article
- Cellular and behavioral outcomes of dorsal striatonigral neuron ablation: new insights into striatal functions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Dissociable effects of dopamine on learning and performance within sensorimotor striatum.Basal ganglia · 2014Article
- Cerebellar potentiation and learning a whisker-based object localization task with a time response window.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Ventral striatum lesions enhance stimulus and response encoding in dorsal striatum.Biological psychiatry · 2014Article
- Striatal direct and indirect pathways control decision-making behavior.Frontiers in psychology · 2014Review
- Reward-modulated motor information in identified striatum neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Speech serial control in healthy speakers and speakers with hypokinetic or ataxic dysarthria: effects of sequence length and practice.Frontiers in human neuroscience · 2013Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dorsal striatum, which contains the dorsolateral striatum (DLS) and dorsomedial striatum (DMS), integrates the acquisition and implementation of instrumental learning in cooperation with the nucleus accumbens (NAc). The dorsal striatum regulates the basal ganglia circuitry through direct and indirect pathways. The mechanism by which these pathways mediate the learning processes of instrumental actions remains unclear. We investigated how the striatal indirect (striatopallidal) pathway arising from the DLS contributes to the performance of conditional discrimination. Immunotoxin targeting of the striatal neuronal type containing dopamine D(2) receptor in the DLS of transgenic rats resulted in selective, efficient elimination of the striatopallidal pathway. This elimination impaired the accuracy of response selection in a two-choice reaction time task dependent on different auditory stimuli. The impaired response selection was elicited early in the test sessions and was gradually restored as the sessions continued. The restoration from the deficits in auditory discrimination was prevented by excitotoxic lesion of the NAc but not by that of the DMS. In addition, lesion of the DLS mimicked the behavioral consequence of the striatopallidal removal at the early stage of test sessions of discriminative performance. Our results demonstrate that the DLS-derived striatopallidal pathway plays an essential role in the execution of conditional discrimination, showing its contribution to the control of selection accuracy of learned motor responses. The results also suggest the presence of a mechanism that compensates for the learning deficits during the repetitive sessions, at least partly, demanding accumbal function.
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