ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Antidepressant suppression of non-REM sleep spindles and REM sleep impairs hippocampus-dependent learning while augmenting striatum-dependent learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 66 citations in OpenAlex.
- Trial
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- Neural circuits linking sleep and addiction: Animal models to understand why select individuals are more vulnerable to substance use disorders after sleep deprivation.Neuroscience and biobehavioral reviews · 2020Review
- Decreased serum potassium may disturb sleep homeostasis in essential hypertensives.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory.Current biology : CB · 2018Article
- Sleep-dependent reconsolidation after memory destabilization in starlings.Nature communications · 2018Article
- Acute Low Alcohol Disrupts Hippocampus-Striatum Neural Correlate of Learning Strategy by Inhibition of PKA/CREB Pathway in Rats.Frontiers in pharmacology · 2018Article
- Imbalance between TNFα and progranulin contributes to memory impairment and anxiety in sleep-deprived mice.Scientific reports · 2017Article
- Sleep Is for Forgetting.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Sleep Spindles as Facilitators of Memory Formation and Learning.Neural plasticity · 2016Review
- Stress-free automatic sleep deprivation using air puffs.Journal of neuroscience methods · 2015Article
- Sleep alterations following exposure to stress predict fear-associated memory impairments in a rodent model of PTSD.Experimental brain research · 2015Article
- The role of REM sleep theta activity in emotional memory.Frontiers in psychology · 2015Review
- Transiently increasing cAMP levels selectively in hippocampal excitatory neurons during sleep deprivation prevents memory deficits caused by sleep loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Trauma exposure and sleep: using a rodent model to understand sleep function in PTSD.Experimental brain research · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Rapid eye movement (REM) sleep enhances hippocampus-dependent associative memory, but REM deprivation has little impact on striatum-dependent procedural learning. Antidepressant medications are known to inhibit REM sleep, but it is not well understood if antidepressant treatments impact learning and memory. We explored antidepressant REM suppression effects on learning by training animals daily on a spatial task under familiar and novel conditions, followed by training on a procedural memory task. Daily treatment with the antidepressant and norepinephrine reuptake inhibitor desipramine (DMI) strongly suppressed REM sleep in rats for several hours, as has been described in humans. We also found that DMI treatment reduced the spindle-rich transition-to-REM sleep state (TR), which has not been previously reported. DMI REM suppression gradually weakened performance on a once familiar hippocampus-dependent maze (reconsolidation error). DMI also impaired learning of the novel maze (consolidation error). Unexpectedly, learning of novel reward positions and memory of familiar positions were equally and oppositely correlated with amounts of TR sleep. Conversely, DMI treatment enhanced performance on a separate striatum-dependent, procedural T-maze task that was positively correlated with the amounts of slow-wave sleep (SWS). Our results suggest that learning strategy switches in patients taking REM sleep-suppressing antidepressants might serve to offset sleep-dependent hippocampal impairments to partially preserve performance. State-performance correlations support a model wherein reconsolidation of hippocampus-dependent familiar memories occurs during REM sleep, novel information is incorporated and consolidated during TR, and dorsal striatum-dependent procedural learning is augmented during SWS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.