ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Ionic current correlations underlie the global tuning of large numbers of neuronal activity attributes.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 50 citations in OpenAlex.
- Conductance relationships across compartments associated with bursting output in a model of a motor neuron in the crustacean cardiac ganglion.Journal of neurophysiology · 2026Article
- Plasticity in voltage-gated ion channels following overwintering in respiratory motoneurons of American bullfrogs.The Journal of experimental biology · 2025Article
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- Alterations in network robustness upon simultaneous temperature and pH perturbations.Journal of neurophysiology · 2024Article
- Motor neurons within a network use cell-type specific feedback mechanisms to constrain relationships among ion channel mRNAs.Journal of neurophysiology · 2023Article
- Heterogeneous off-target impact of ion-channel deletion on intrinsic properties of hippocampal model neurons that self-regulate calcium.Frontiers in cellular neuroscience · 2023Article
- Homeostatic regulation of neuronal function: importance of degeneracy and pleiotropy.Frontiers in cellular neuroscience · 2023Review
- Pareto optimality, economy-effectiveness trade-offs and ion channel degeneracy: improving population modelling for single neurons.Open biology · 2022Review
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- Circuit Stability to Perturbations Reveals Hidden Variability in the Balance of Intrinsic and Synaptic Conductances.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Membrane Voltage Is a Direct Feedback Signal That Influences Correlated Ion Channel Expression in Neurons.Current biology : CB · 2019Article
- Modulator-Gated, SUMOylation-Mediated, Activity-Dependent Regulation of Ionic Current Densities Contributes to Short-Term Activity Homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow.PLoS computational biology · 2018Article
- Origin of heterogeneous spiking patterns from continuously distributed ion channel densities: a computational study in spinal dorsal horn neurons.The Journal of physiology · 2018Article
- A balance of outward and linear inward ionic currents is required for generation of slow-wave oscillations.Journal of neurophysiology · 2017Article
- Activation mechanism of a neuromodulator-gated pacemaker ionic current.Journal of neurophysiology · 2017Article
- Mechanisms of generation of membrane potential resonance in a neuron with multiple resonant ionic currents.PLoS computational biology · 2017Article
- Genetic perturbations suggest a role of the resting potential in regulating the expression of the ion channels of the KCNA and HCN families in octopus cells of the ventral cochlear nucleus.Hearing research · 2017Article
- The complexity of small circuits: the stomatogastric nervous system.Current opinion in neurobiology · 2016Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ionic conductances in identified neurons are highly variable. This poses the crucial question of how such neurons can produce stable activity. Coexpression of ionic currents has been observed in an increasing number of neurons in different systems, suggesting that the coregulation of ionic channel expression, by thus linking their variability, may enable neurons to maintain relatively constant neuronal activity as suggested by a number of recent theoretical studies. We examine this hypothesis experimentally using the voltage- and dynamic-clamp techniques to first measure and then modify the ionic conductance levels of three currents in identified neurons of the crab pyloric network. We quantify activity by measuring 10 different attributes (oscillation period, spiking frequency, etc.), and find linear, positive and negative relationships between conductance pairs and triplets that can enable pyloric neurons to maintain activity attributes invariant. Consistent with experimental observations, some of the features most tightly regulated appear to be phase relationships of bursting activity. We conclude that covariation (and probably a tightly controlled coregulation) of ionic conductances can help neurons maintain certain attributes of neuronal activity invariant while at the same time allowing conductances to change over wide ranges in response to internal or environmental inputs and perturbations. Our results also show that neurons can tune neuronal activity globally via coordinate expression of ion currents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.