Evidence map›Paper›PMID 23015276›Full record

ArticleThe European physical journal. E, Soft matter2012

Rupture of multiple receptor-ligand bonds: bimodal distribution of bond rupture force.

V K Gupta

Abstract read
PubMed Publisher
In one paragraph

Article in The European physical journal. E, Soft matter, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Rupture of multiple catch-slip bonds: Two-state two-pathway catch-slip bonds.The European physical journal. E, Soft matter · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

V K GuptaUniversity of Maryland Baltimore County, Baltimore, Maryland 21250, USA. vkg@umbc.edu
University of Maryland, Baltimore County · US

Funding

Computational model of cellular adhesion in bulk flowsR01AI063366 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI EGGLETON, CHARLES DIONISIO · 2005 to 2009
$1.5M
NIAID NIH HHS R01 AI063366
6 · The paper itself

Abstract

Monte Carlo simulation of the rupture of multiple receptor-ligand bonds between two PMN cells suspended in a Newtonian fluid is performed. In the presence of a hydrodynamic drag force acting on two PMN cells the interplay of multiple receptor-ligand bonds between these cells leads to a bimodal distribution of the bond rupture force at certain loading rates. Specifically, it is found that the interplay of multiple bonds between two PMN cells in the presence of hydrodynamic drag force acting on these cells modifies the bond energy landscape in such a way as to lead to a bimodal distribution of the bond rupture force where a low force peak switches to a high force peak as the loading rate is increased progressively, characteristics of two-state systems.

Indexed as

Mechanical PhenomenaModels, BiologicalMonte Carlo MethodBiomechanical PhenomenaCell Adhesion MoleculesHydrodynamicsLigandsNeutrophilsProtein BindingThermodynamicsCell Adhesion MoleculesLigands

Identifiers

PMID23015276
OpenAlexW2005137475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.